Comments on: Gene Therapy for blindness http://speakingofresearch.com/2008/04/30/gene-therapy-for-blindness/ Improving understanding about Animal Research / Animal Testing Mon, 13 Feb 2012 17:45:45 +0000 hourly 1 http://wordpress.com/ By: Gene therapy for blindness – when dogged determination pays off! « Speaking of Research http://speakingofresearch.com/2008/04/30/gene-therapy-for-blindness/#comment-1029 Mon, 02 Nov 2009 03:01:31 +0000 http://speakingofresearch.wordpress.com/?p=96#comment-1029 [...] one of my first posts for Speaking of Research last year I discussed on this blog how two teams of scientists at Moorfields hospital in the UK and the University of [...]

]]> By: Paul http://speakingofresearch.com/2008/04/30/gene-therapy-for-blindness/#comment-128 Tue, 09 Sep 2008 09:42:45 +0000 http://speakingofresearch.wordpress.com/?p=96#comment-128 Following up on the two trials reported above a third clinical trial published this week in the journal Human Gene Therapy (1) has also reported that gene therapy with RPE65 improved vision in three patients with Leber’s congenital amaurosis.

This trial was a phase I trial whose main purpose was to assess the safety of the treatment, but which also measured changes to vision. A major difference between this study and the previous two studies is that the immune system of the patients was not suppressed before the treatment. Previously it had been believed that the immune system might block the treatment, but this study indicates that this is doesn’t happen. You can find out more about the new trial on <>

1) Hausewirth W.W. “Phase I Trial of Leber Congenital Amaurosis due to RPE65 Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results.” Human Gene Therapy Online September 7 2008. <>

]]>