Monthly Archives: May 2008

The Animal Research War – Revealing the truth about Animal Rights Extemism

The Animal Research War exposes the tactics of animal extremists for what they are ‐ terrorism. The actions of a tiny minority have seriously set back the progress of research aimed at reducing the suffering of people and animals. It is time for scientists, patients and all who abhor the use of terror to stand up for the future of medical research.
‐‐ Dr. Colin Blakemore, former Chief Executive, Medical Research Council UK

Michael Conn and James Parker explore the history and progression of the animal rights movement in the US, in this new book.

For anyone interested in exploring the ideas behind animal rights extremism, this book investigates some of the main players in the animal rights movement. From Rick Bogle and Matt Rossell, to PeTA and the ALF, this book looks at the progress of these individuals and organizations, as well as many others. There is also some solid arguments on the importance of animal research scattered throughout the book. If you click on The Animal Model you will find an excerpt from the book detailing why we need to use animals to model diseases, using the example of AIDS.

The book is available on Amazon.

Tom

SR on YouTube!

For a long time, animal rights groups have taken advantage of new social media tools that exist on the web. Their presence dominates and clouds the issue of animal research, meaning that individuals looking for information on animal research, find themselves faced “Vivisection kills”, “Stop Torture”. Pro-Test broke the mold by being the first group in support of animal research that took advantage of these new opportunities. Pro-Test’s Facebook page is a baker’s dozen shy of 3,000 members, and the group also has a presence on MySpace and Wikipedia.

Now it’s Speaking of Research’s turn to bring a fresh angle to the debate on animal research – YouTube. When you type “animal research” or “animal testing” into YouTube you get a torrent of animal rights videos, well this is only a start, but now we have at least one video providing the unclouded truth about animal research.

View on YouTube, or see it embedded below.

So help Speaking of Research. Favourite the video, give it a good rating, and leave some positive feedback – I’ll be keeping an eye on the comments.

I would like to thank Oregon Health & Sciences University for recording the presentation and sending me a DVD that I could edit into this piece.

Cheers
Tom

Vlasak: A Wolf in Sheep’s Clothing?

Jerry Vlasak is a high profile animal rights activist, and one of the three spokesmen for the North American Animal Liberation Press Office (ALPO), an organization which reports acts of violence and vandalism carried out by the Animal Liberation Front (ALF) and Animal Rights Militia (ARM). He was formerly a spokesman for Physicians Committee for Responsible Medicine (PCRM). He is married to Pamelyn Ferdin, former-president of Stop Huntingdon Animal Cruelty (SHAC).

Vlasak has also made news repeatedly for claiming it would be morally acceptable to kill researchers:
Jerry VlasakI think there is a use for violence in our movement. And I think it can be an effective strategy. Not only is it morally acceptable, I think that there are places where it could be used quite effectively from a pragmatic standpoint.
For instance, if vivisectors were routinely being killed, I think it would give other vivisectors pause in what they were doing in their work [...] And I don’t think you’d have to kill — assassinate — too many vivisectors before you would see a marked decrease in the amount of vivisection going on.

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On the other side of the coin, Vlasak claims to be a practicing trauma surgeon, lending credibility to the animal rights movement of which he is a part of. He alleges not to be misanthropist, hiding behind his position as a practicing trauma surgeon – “I save lives everyday at the hospital. Everyday, I go to the hospital, I save lives,” (KUTV). So where exactly does he go everyday to practice medicine?

Senate Committee Hearing 2005:
Dr. Vlasak. I attended medical school at the University of Texas, in Houston.
Senator Lautenberg. And where do you practice now?
Dr. Vlasak. I practice in the Los Angeles area.
Senator Lautenberg. At a hospital?
Dr. Vlasak. I do. A number of hospitals.
Senator Lautenberg. What is your favorite, what is your dominant hospital activity?
Dr. Vlasak. I practice at several hospitals in the Riverside and San Bernadino area.
Senator Lautenberg. Name one.
Dr. Vlasak. Loma Linda University.

Some claim considering that LA Weekly discovered he had in fact resigned from general surgery at Linda Loma University in 1998. I decided to do a little digging myself, scouring the internet for references to hospitals in which Vlasak stated to practice surgery (and some others which fit descriptions for hospitals he claims to have worked in e.g. Loma Linda University Medical Center).
Loma Linda University
Loma Linda University Medical Center
Riverside Community Hospital
Parkview Community Hospital
San Bernardino Community Hospital
San Antonio Community Hospital
Arrowhead Regional Medical Center

Of those seven medical establishments, two stated Vlasak had formerly worked there, the rest simply did not know who he was and could not find him on their medical registers.

One must wonder what Vlasak does when “Everyday, [he] go[es] to the hospital”?

Cheers

Tom

Animal research behind the headlines

The BBC has reported on calls for the new blood-thinning drug Pradaxa (dabigatran etexilate/BIBR 1048) to be used more widely in patients who are at risk of blood clots following surgery, a serious complication that kills 25,000 patients each year. This drug works be inhibiting the enzyme Thrombin, a key player in clot formation.

http://news.bbc.co.uk/1/hi/health/7354818.stm

Clinical trials indicate that  thew new drug is as effective at preventing clotting as existing treatments, but that it is easier to get the dose right and that overall it is significantly safer. Another advantage is that it is taken as a pill rather than requiring daily injections, such injections are often painful and can lead patients to stop taking anticoagulant drugs such as heparin. Several large scale trials of Pradaxa are underway, and it is undergoing assessment by the UK’s National Institute for Health and Clinical Excellence, although it has already been licensed for patients undergoing knee and hip operations on the NHS.

http://www.medicalnewstoday.com/articles/101952.php

We hope that the larger trials go well and that this drug is approved for use by NICE. In the meanwhile it’s worthwhile to take a look at the contribution made by animal research to its development, and the role of animals alongside other computational, chemical and in vitro methods.

As is usual the early design of this drug relied on computer aided analysis of the structure of thrombin and in vitro studies using human thrombin (1).  This analysis yielded a number of candidate molecules which were assessed for their ability to inhibit thrombin in rats and rabbits, and eventually one was identified that combined a potent ability to inhibit thrombin with low toxicity, even at high doses.  Unfortunately this molecule was not active when given orally, it needed to be injected, so it was further modified in an attempt to make a drug that could be given in pill form.  Several candidate drugs were assessed in rabbits and subsequently in monkeys and one, BIBR 1048, was found to have very good anticoagulant activity when given orally (1).  On the basis of these results, and of course additional regulatory toxicity tests, BIBR 1048 was selected to go into clinical trials.

Cheers

Paul Browne

1) Hauel N.H. et al. “Structure-based design of novel potent nonpeptide thrombin inhibitors.” J Med Chem. Volume 45, Issue 9, Pages 1757-66 (2002) PubMed: 11960487.