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	<title>Comments on: Three Young Advocates Step Up</title>
	<atom:link href="http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/feed/" rel="self" type="application/rss+xml" />
	<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/</link>
	<description>Defending Animal Research</description>
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		<title>By: suzana Megles</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-777</link>
		<dc:creator>suzana Megles</dc:creator>
		<pubDate>Sat, 08 Aug 2009 14:34:50 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-777</guid>
		<description>To call PCRM doctors a bunch of lunatics is cruel and unkind.  They have been instrumental for closing a lot of unnecessary dog labs in many of the most prestigious medical teaching hospitals where other digital means are now effectively  being used.  Pretty good and compassionate work for these &quot;lunatics.&#039;&#039;   And guess what -the medical association is finally jumping on THEIR bandwagon re the importance of diet for health.  Too much meat and dairy is being linked to cancer, heart problems, and diabetes.  Again not too bad for a bunch of lunatics.  God bless their noble work.</description>
		<content:encoded><![CDATA[<p>To call PCRM doctors a bunch of lunatics is cruel and unkind.  They have been instrumental for closing a lot of unnecessary dog labs in many of the most prestigious medical teaching hospitals where other digital means are now effectively  being used.  Pretty good and compassionate work for these &#8220;lunatics.&#8221;   And guess what -the medical association is finally jumping on THEIR bandwagon re the importance of diet for health.  Too much meat and dairy is being linked to cancer, heart problems, and diabetes.  Again not too bad for a bunch of lunatics.  God bless their noble work.</p>
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		<title>By: suzana Megles</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-776</link>
		<dc:creator>suzana Megles</dc:creator>
		<pubDate>Sat, 08 Aug 2009 14:27:17 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-776</guid>
		<description>I&#039;m glad you are such a spelling purist.  We are all entitled to spelling and grammatical errors from time to time but to dismiss my thoughts for a spelling error borders on the ridiculous.  Look at the content- not the spelling!</description>
		<content:encoded><![CDATA[<p>I&#8217;m glad you are such a spelling purist.  We are all entitled to spelling and grammatical errors from time to time but to dismiss my thoughts for a spelling error borders on the ridiculous.  Look at the content- not the spelling!</p>
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		<title>By: Paul Browne</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-745</link>
		<dc:creator>Paul Browne</dc:creator>
		<pubDate>Thu, 23 Jul 2009 13:59:16 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-745</guid>
		<description>AronC, where to start!

Chimpanzees may not naturally get HIV, and if given it do not usually go on to develop AIDS, but they can naturally get a strain of SIV (SIVcpz) that causes AIDS and results in a 10-16 fold increase mortality in wild chimps, which is intermediate between that seen with HIV-1 in humans and that seen for HIV-2 in humans.

This is interesting because phylogenetic analysis indicates that SIVcpz is the direct ancestor of HIV-1, which probably arose when a strain of SIVcpz jumped species into humans about 100 years ago. SIVcpz itself was probably acquired by chimps from the monkeys they eat about 500 years ago.

See: Keele B.F et al. Nature Vol 460, 23 July 2009, doi:10.1038/nature08200

Chimpanzees certainly get Hepatitis B, which again occurs naturally in chimpanzee populations
See: Hu X. et al. Proc Natl Acad Sci U S A. 2000 February 15; 97(4): 1661–1664. 
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=10677515

Finally while chimpanzees are resistant to the malaria parasite Plasmodium falciparum they do suffer in the wild from infection by the closely related malaria parasite Plasmodium reichenowi.
Martin M.J. et al. Proc Natl Acad Sci U S A. Vol. 6;102(36):12819-12824 (2005)

There&#039;s actually a lot of interest in the scientific community in looking at differences in susceptibility to different infectious diseases between closely related species, and between sub-species, as this may provide important clues as to how to develop more effective treatments or prevention strategies.</description>
		<content:encoded><![CDATA[<p>AronC, where to start!</p>
<p>Chimpanzees may not naturally get HIV, and if given it do not usually go on to develop AIDS, but they can naturally get a strain of SIV (SIVcpz) that causes AIDS and results in a 10-16 fold increase mortality in wild chimps, which is intermediate between that seen with HIV-1 in humans and that seen for HIV-2 in humans.</p>
<p>This is interesting because phylogenetic analysis indicates that SIVcpz is the direct ancestor of HIV-1, which probably arose when a strain of SIVcpz jumped species into humans about 100 years ago. SIVcpz itself was probably acquired by chimps from the monkeys they eat about 500 years ago.</p>
<p>See: Keele B.F et al. Nature Vol 460, 23 July 2009, doi:10.1038/nature08200</p>
<p>Chimpanzees certainly get Hepatitis B, which again occurs naturally in chimpanzee populations<br />
See: Hu X. et al. Proc Natl Acad Sci U S A. 2000 February 15; 97(4): 1661–1664.<br />
<a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=10677515" rel="nofollow">http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=10677515</a></p>
<p>Finally while chimpanzees are resistant to the malaria parasite Plasmodium falciparum they do suffer in the wild from infection by the closely related malaria parasite Plasmodium reichenowi.<br />
Martin M.J. et al. Proc Natl Acad Sci U S A. Vol. 6;102(36):12819-12824 (2005)</p>
<p>There&#8217;s actually a lot of interest in the scientific community in looking at differences in susceptibility to different infectious diseases between closely related species, and between sub-species, as this may provide important clues as to how to develop more effective treatments or prevention strategies.</p>
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		<title>By: Denis Alexander</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-744</link>
		<dc:creator>Denis Alexander</dc:creator>
		<pubDate>Thu, 23 Jul 2009 03:09:35 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-744</guid>
		<description>You mean &quot;research&quot;...   nobody &quot;vivisects&quot; any more.  Who invented that word?</description>
		<content:encoded><![CDATA[<p>You mean &#8220;research&#8221;&#8230;   nobody &#8220;vivisects&#8221; any more.  Who invented that word?</p>
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		<title>By: Denis Alexander</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-743</link>
		<dc:creator>Denis Alexander</dc:creator>
		<pubDate>Thu, 23 Jul 2009 03:08:52 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-743</guid>
		<description>It feels the same as undergoing surgery.  Anesthesia, analgesia, and a good cocktail for memory amnesia.  Next time you need surgery remember -- 100 years ago, all you had was a big bottle of whiskey (or opium) to endure the pain.</description>
		<content:encoded><![CDATA[<p>It feels the same as undergoing surgery.  Anesthesia, analgesia, and a good cocktail for memory amnesia.  Next time you need surgery remember &#8212; 100 years ago, all you had was a big bottle of whiskey (or opium) to endure the pain.</p>
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		<title>By: Denis Alexander</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-742</link>
		<dc:creator>Denis Alexander</dc:creator>
		<pubDate>Thu, 23 Jul 2009 03:06:08 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-742</guid>
		<description>Could not agree more with you Prof. Jentsch!</description>
		<content:encoded><![CDATA[<p>Could not agree more with you Prof. Jentsch!</p>
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		<title>By: Denis Alexander</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-741</link>
		<dc:creator>Denis Alexander</dc:creator>
		<pubDate>Thu, 23 Jul 2009 03:05:44 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-741</guid>
		<description>PCRM is nothing but a source of information.  It is nothing more than PeTA with white coats.   JAMA ran an article not long ago distancing the medical profession from this group of lunatics.</description>
		<content:encoded><![CDATA[<p>PCRM is nothing but a source of information.  It is nothing more than PeTA with white coats.   JAMA ran an article not long ago distancing the medical profession from this group of lunatics.</p>
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		<title>By: Denis Alexander</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-740</link>
		<dc:creator>Denis Alexander</dc:creator>
		<pubDate>Thu, 23 Jul 2009 03:04:12 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-740</guid>
		<description>Congrats Gillian!!!  We look forward to your great work of educating the public and gathering support for the future of science and medicine!</description>
		<content:encoded><![CDATA[<p>Congrats Gillian!!!  We look forward to your great work of educating the public and gathering support for the future of science and medicine!</p>
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	<item>
		<title>By: speakingofresearch</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-739</link>
		<dc:creator>speakingofresearch</dc:creator>
		<pubDate>Thu, 23 Jul 2009 00:08:54 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-739</guid>
		<description>However monkeys do get SIV - which is a very good model for the human version. Whereas the disease was once a definite death sentence it is now a manageable chronic disease whereby those with it can live relatively normal lives. Thanks for HAART developed through monkey SIV models.

What do you mean the surrounding factors weren&#039;t there - HIV can come about by tainted blood or having sex - how you got it is largely irrelevant in finding a treatment.</description>
		<content:encoded><![CDATA[<p>However monkeys do get SIV &#8211; which is a very good model for the human version. Whereas the disease was once a definite death sentence it is now a manageable chronic disease whereby those with it can live relatively normal lives. Thanks for HAART developed through monkey SIV models.</p>
<p>What do you mean the surrounding factors weren&#8217;t there &#8211; HIV can come about by tainted blood or having sex &#8211; how you got it is largely irrelevant in finding a treatment.</p>
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		<title>By: Simon Templar</title>
		<link>http://speakingofresearch.com/2009/07/16/three-young-advocates-step-up/#comment-736</link>
		<dc:creator>Simon Templar</dc:creator>
		<pubDate>Tue, 21 Jul 2009 11:58:17 +0000</pubDate>
		<guid isPermaLink="false">http://speakingofresearch.com/?p=888#comment-736</guid>
		<description>No, just none for animal rights activists.</description>
		<content:encoded><![CDATA[<p>No, just none for animal rights activists.</p>
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