Monthly Archives: March 2011

The Human or the Mouse? Would You Flip a Coin?

On March 8th I debated Prof. Gary Francione at Rutgers.

It was an interesting, heated but civil debate, with a somewhat anticipated outcome. 

In a few words, we have profound, irreconcilable differences. 

There is a deep, fundamental gap between the views of the vast majority of the public and anyone whose moral theory declares permissible to flip a coin in order to decide who to save in a burning house, a human or a mouse.  

And this is exactly what Prof. Francione and a handful of his followers (about 5 out of 120 members in the audience) were prepared to do .  Of course, they are right.  They are right in that this is precisely what Prof. Francione’s theory of animal rights demands them to do.  Why?  Because the theory considers the mouse and the human as both sentient beings that deserve exactly the same level of moral consideration. 

The root of our differences can be traced down to his position that there are no morally relevant characteristics that would make the loss of life for the human any different than the loss of life for the mouse.  Prof. Francione view is that the same things are at stake.

Here, of course, he stands against the philosophical current:

For example, Peter Singer recognizes that

to take the life of a being who has been hoping, planning and working for some future goal is to deprive that being of the fulfillment of those efforts; to take the life of a being with a mental capacity below the level needed to grasp that one is a being with a future — much less make plans for the future — cannot involve this particular kind of loss.”

Ortega y Gasset explained that

Human life is the execution of an aspiration — a life’s plan.  Human life is a process that cannot be reduced to mere living by satisfying our immediate biological needs.  Humans are not content with living, they need to live well and realize their ambitions.” 

and this, of course, is a relevant reason why animal and human interest in life are not similar.  

Tom Regan agrees when he writes

“[...] the harm that death is, is a function if the opportunities for satisfaction it forecloses, and no reasonable person would deny that the death of any [...] human would be a greater prima facie loss, and thus a greater prima facie harm, that would be true in the case [of] a dog”

In my opening remarks, I presented reasons for why we must reject the animal rights view, which equates the moral status of all sentient beings.  I did this by giving examples of how applying the theory to various scenarios would lead us to behave in ways that conflict with our moral intuitions.  I argued that once we reject this extreme view, all we are only left with theories based on the notion of unequal moral status between animals and normal humans (such as the two-tier or sliding scale model of moral status).  All of these theories allow animal experimentation to various degrees.   

I explained how researchers view very concrete situations as being comparable to the burning house scenario, such as porcine heart-valve replacement surgery, the polio epidemic or the AIDS epidemic in Africa.

I explained also why I believe we have obligations to other living beings, but that these obligations do not imply that animals have rights, as they cannot behave as autonomous, rational moral agents in a community of equals.   This, of course, is a point made by Carl Cohen in various occasions

Unfortunately, there was no effort on Prof. Francione’s part to pinpoint the flaws in my reasoning.  One of the virtues of his theory is that it is extremely simply to understand, extremely simple to apply, and the consequences are straightforward.   My main point was that the consequences of the theory are in direct conflict with the moral intuition of the vast majority of the public and we must reject it.

Instead, his attacks on animal research amounted to a potpourri of classic mischaracterizations by animal right activists of the actual science, our true intentions, and personal ethics, all of which are difficult to address in a few minutes in a debate.

For example, I pointed out to the use of primates in the development of the polio vaccine that has helped to nearly eradicated the disease from the face of the planet and will continue to save lives for generations to come.  The benefits are unmeasurable.  He responded that animals were not truly needed in the development of the vaccine, in direct contradiction to statements by Dr. Albert Sabin.

I noted that there is vast scientific consensus (92% agreement) from both scientists and physicians alike on the necessity of animal research to advance medical science and knowledge.  He countered that, on this matter, the jury is still out.

He criticized the scientific community for not including mice and rats in the animal welfare act (AWA), but his true position was exposed when he declared the AWA “not worth the paper on which it is written”.   Let us be clear: there are no amendments to the AWA whatsoever that would make the research ethical in the view of animal rights activists. 

He criticized me for not being vegan, while it is evident that even if all scientists were to become vegan tomorrow the research would still be viewed as unethical in their eyes.  (Incidentally, I think the ethics of animal food can be defended, but this is an entirely different topic and debate).

I clarified that I am opposed to the use of animals for the development of yet another lipstick, but that there is an obvious need to ensure that any chemicals we bring to our homes are safe to humans and animals alike.  I also noted this is not the type of toxicology work done at our universities.

During our mutual questioning I asked him if his education campaign to break the cycle of “supply and demand” of animal food also extended to the benefits generated by animal research, such as vaccines.  In other words, was he willing to ask the population at large to stop vaccinating their children? 

He responded that in fact he would not vaccinate his children (he has none, although he did not say if his dogs are vaccinated), and later he clarified his opposition to vaccination rests not only for ethical but other reasons, which he never explained.  I expressed my dismay at his anti-vaccination position.

Many of the questions directed at me by the audience dealt with the question of moral status of animals and humans.  I explained that I do not claim the moral status of all humans is above the moral status of all animals.  A number of questions regarding marginal cases ensued.   I think this can be a productive and interesting discussion to have in society, but it is only a discussion that is possible once we accept the unequal moral status of animals and normal humans.   Clearly, it is not a discussion that is even theoretically possible within the framework of animal rights theory that equates the moral status of all sentient beings.

I had a nice and frank conversation with Prof. Francione prior to the debate.  As he correctly judged, our positions are “miles apart”.  My perception is that he is a good man, with noble intentions, but philosophically he is as wrong as anyone can be.   

Both Prof. Francione and I agreed on one thing: the debate was a good example of how passionate but respectful discourse is possible on controversial issues in our society.  I want to publicly thank him for his invitation to debate.

Prof. Francione and I will share a video of the entire event once it is ready.

Dario Ringach

Loving Animals…While Throwing Humans Under the Bus

Recently, the Sunday New York Times ran cover story on efforts to combat the obesity epidemic and the role of animal research in this battle. It’s not surprising that those opposed to animal studies reacted.

What is surprising is what they said. The organization which conducted the studies  - the OHSU Oregon National Primate Research Center- has received countless emails. Many were automated messages from change.org. However, instead of cutting and pasting the same identical message,some individuals did share their own thoughts via email, Facebook and message boards.

(Too) many contained comments such as these:

“You’re WASTING tax money torturing animals to find a “treatment” for FAT PEOPLE ?!”

“If you want to study the morbidly obese why not walk down to your local fast food place and great a few people. I am sure they won’t run away too fast. You could net 3 or 4 pretty easy. “

“Don’t they know there is enough fat slobs in the world to do studdies on!”

“Ask the blimps walking around in your downtown.”

“We know the reasons that fat people are fat. Experiment on fat people.”

“This is disgusting. There are enough train wrecks waddling around out there that this experimentation is totally unnecessary.”

“If people choose to continue to be morbidly obese, not contribute to society and sit around killing themselves with food and do not get help through an ENDOCRINOLGIST – and become a constant burden to taxpayers in these trying economic times -let them”.

“This is totally repulsive how Americans can test and kill these poor monkeys just so that the FAT PIG AMERICANS can keep shoveling more and more into their fat heads. Instead of killing the monkeys why don’t you fat pigs just stop eating. Oh ya I forgot you Americans want everything. I hope all you fat people today, after reading this story choke on whatever maybe in your mouth and drop dead.”

“Hey, stupid people, stop cramming crap in your mouth,” get your fat ass off the couch and go walk around the block. You don’t need a pill, you need to stop being lazy, you are fat because of it’s your own damn fault. Look at what your laziness causes, millions wasted on pointless research, your fat ass is killing these monkeys so they can find a pill so your fat ass can stay skinny while your gorge yourself from your trough in front of your thought dictator.”

“A friend of mine told me that what a BUFFET means-Big Ugly Fat Folks Eating Together.” (posted by a person who said they were a scientist)

What’s striking about all these responses is that so many people are quick to state their compassion to animals while at the same time showing no compassion whatsoever to other humans (also animals).

Of course, most Americans realize that obesity is not just a personal choice and the causes of the epidemic and more complex than > food = obesity. Both animal studies and human studies demonstrate that there is a significant genetic component to the disease meaning that while some folks have no problem maintaining a healthy weight, many others become overweight even though they maintain a healthy diet.

We also know that the solutions to obesity are not easy. Ever wonder why so many people go on diets only to gain the weight back? The dieters didn’t fail…your brain actually responds to weight loss and literally fights to put those pounds back on. Studies in animals revealed this amazing discovery. In addition, new research has demonstrated that the current epidemic will likely impact several generations in the future.

Furthermore  - there is an economic component to the obesity epidemic. While many of us have access to healthy foods, the reality is that those with limited funds do not. Lower income families often do not have a car. They shop at the corner market where only processed foods are available. When they eat out, few low-fat, healthy choices are available.

So what can be done?

Studies in both humans and animals must continue to provide us with answers and new solutions to help those who want to lose weight keep it off.

In addition, people need to start realizing that seemingly simple problems are often very complex. Until that time…those who oppose animal studies will continue to have a large audience.

Regards,

Speaking of Research

“Successes of Antivivisection Activists” are delusions, at best

The North American Animal Liberation Press Office drew upon the recent profile of UCLA researchers by the Chronicle of Higher Education in a recent post (warning: extremist website), boasting that information in the article:

validates activists’ tactics and achievements in making the abuse of animals more costly and dangerous for the evil men and women who insist on putting their own careers and greed over the suffering and lives of innocent animals.

What the statement by NAALPO misses, in its simple-minded misstatements of facts regarding research at UCLA, is that biomedical research, including that which involves animal subjects, is going strong on this campus, as it is on others across the world. Certainly, my own research, which in part focuses on the biological mechanisms that mediate addictions, continues unabated. It is humane and responsible, and it progresses. Insinuating that animal rights activists have driven down the number of animals used at UCLA, the NAALPO author indicates that the Chronicle article fails:

…to account for the hundreds of lemur monkeys recently transferred from UCLA to an east coast institution when Lynn Fairbanks gave up her research on them here.

Firstly, lemurs are not monkeys; they are prosimians. Secondly, UCLA never had a colony of lemurs; the animal resource in question is a colony of pedigreed vervet monkeys that now resides at the Wake Forest Primate Research Center. Thirdly, according to Lynn Fairbanks – a member of the Speaking of Research and Pro-test for Science committees,

our partnership with [Wake] has enabled us to expand our research on environmental and genetic origins of psychopathology.

 

Commenting on the move, David Friedman, professor of physiology and associate dean for research at Wake Forest University School of Medicine, who uses behaviorally phenotyped colony animals in his own research on the etiology of alcoholism, told us that:

The vervet research colony was relocated in order to facilitate research teams and institutions working together to concentrate expertise and promote collaboration and to maximize the use of an invaluable animal model for research relevant to a broad range of diseases, including addiction, psychiatric disorders, diabetes, cardiovascular diseases and aging.  Having the colony at Wake Forest facilitates all  these efforts and helps to make sure the resource can be even more widely shared and well utilized than it has been in the past”

Dr. Fairbanks continues making important discoveries by studying these vervet monkeys, discoveries that will contribute to the understanding of the causes of behavioral problems like impulse control disorders, and she remains an important advocate for humane biomedical research on animals.

The three serious failures of fact in this one sentence in the NAALPO statement alone belie the ignorance of the entire posting.

What the NAALPO author also misses is that animal numbers usually decrease when a particular program of research is completed and the resulting discoveries are discussed and translated into clinical research, and ultimately to benefits for human society. They also sometimes decrease when scientists discover new ways to refine their procedures and when technological advances permit reductions in numbers of subjects needed to make discoveries.

The NAALPO author goes on to obsess over the costs of federally-funded research at UCLA and the security measures to protect researchers from violent animal rights extremists. What they seem unable to understand is the cost of not doing research… that a human life – that of your child, your mother or your best friend – has no price tag. These costs are easily justified by the need to ensure that families everywhere are able to live happy and healthy lives.

So, for animal rights extremists in Los Angeles, the delusions of grandeur continue, but the successes are few. Dario Ringach puts it best when he says:

Science is a community effort.  My suspension of animal research does not mean the work has stopped.  It is being performed elsewhere by hundreds of talented colleagues.

Basic discoveries that enable the developments of treatments or cures are emerging at a rate never before seen, and this will continue despite efforts of misguided and hate-mongering animal rights activists wherever scientists pursue open discussion of the goals and nature of biomedical research in which they are engaged.

Regards

David Jentsch

Spider silk used to repair nerve damage in sheep

On Friday I discussed some recent developments in use of stem cells to repair spinal cord damage, but central nervous system damage is not the only cause of paralysis; every year many thousands of people become paralysed in a limb due to peripheral nerve damage.

A difference between peripheral nerve damage and central nervous system damage is that in peripheral nerve damage a limited degree of nerve regeneration is often possible, and surgery can be used to reconned severed nerves if the gap is small enough. However, the techniques currently available, while useful, are not always successful.

Continue reading

Transplanted astrocytes repair spinal cord damage in rat

A couple of weeks ago I discussed the launch of two clinical trials of brain machine interfaces designed to allow quadriplegic patients to control a newly designed prosthetic limb, during which I mentioned that scientists are also studying techniques that attempt to repair damage to spinal cords using stem cells.  Several approaches have already shown promise in animal studies, for example oligodendrocyte progenitor cells that are derived from human embryonic stem cells that we have discussed on Speaking of Research before, and olfactory ensheathing cells that continuously regenerate nerve cells in the lining of our noses. Research on the ability of these cells to repair spinal cord damage has depended on animal research, indeed olfactory ensheathing cells were originally identified in rats by Professor Geoffrey Raisman before being confirmed to exist in humans too.

This week a team of scientists working at the University of Rochester and the University of Colorado School of Medicine led by Professor Chris Pröschel have shown in rats that another type of cell can repair spinal cord damage, publishing the results of their study in the open access journal PLoS One.

Sprague-Dawley rats are a very useful model for spinal cord repair. Image courtesy of Understanding Animal Research

Astrocytes are star-shaped glial cells that support nerve cells, and have an important role in the regulation of the transmission of electrical impulses within the brain.  They are also involved in the repair of damaged nerve tissue, prompting scientists to study whether transplanting them at the sites of spinal cord injury can repair damage and restore function, but the results to date have been disappointing.

What Prof. Pröschel’s team showed was that there are functional differences between two distinct subtypes of human astrocytes derived from a common fetal glial precursor population in the ability to promote repair of the injured adult central nervous system, confirming an observation they had previously made is studies of rat glial derived cells (1). When injected at the injury site in rats whose spinal cord had been severed just below the neck on one side, Human fetal glial progenitor cells (hGPCs) which had been treated with bone morphogenetic protein (BMP), a growth factor that plays an important role in regulating the development of many tissues, protected nerve cells and promoted their regrowth, and promoted a substantial improvement locomotor function 28 days after injury and transplantation, as determined by measuring the ability of rats to walk along a horizontal ladder. Conversely hGPCs which had not been treated, or had been treated with the ciliary neurotrophic factor, a growth factor previously identified as playing an important role in astrocyte development, did not protect nerve cells or promote locomotor recovery, despite the observation that they migrated to the same locations within the site of injury as the BMP treated cells.

Earlier studies of the ability of astrocytes to repair spinal cord damage had used mixed astrocyte population, so it is not surprising that they did not see such striking benefits.

 Prof. Pröschel’s team also found that robust functional recovery in the rat was only obtained when hGPCs were pre-differentiated with BMP to produce astrocytes before transplantation, a result in close agreement with their earlier studies of which examined the ability of glial progenitor cells to repair spinal cord damage (1).

Commenting on these exciting results in a report in the Denver Post Prof. Pröschel noted that:

What’s really striking is the robustness of the effect…Scientists have claimed repair of spinal-cord injuries in rats before, but the benefits have been variable and rarely as strong as what we’ve seen with our transplants”

His colleague Stephen Davies indicates that the team is hoping to begin clinical trials of this therapy soon, perhaps even within the next two years:

Now the challenge is how rapidly can we translate these discoveries from the lab for use in humans…We are working hard to translate this technology in the next one to two years. It’s difficult to predict”

His caution is fully justified, regulators are very cautious about giving permission for trials of stem cell based therapies to go ahead, and before doing so they may well demand that further animal studies are undertaken to assess the longer-term safety of hGPC-derived astrocyte transplantation. It is also worth noting that in this study the astrocytes were transplanted on the same day as injury, a time to treatment that will be very difficult to achieve in the clinic.  Before starting clinical trials it would be very advisable to determine how effective the treatment is at a series of time points up to 14 days after injury, in order to determine the length of the time window within which the treament must be started.

Nevertheless, this is a very promising study that, in addition to being important and interesting in its own right, adds to the growing body of evidence supporting the potential of stem cell therapy to repair spinal cord damage and prevent paralysis.

Paul Browne

1)    Davies JE, Proschel C, Zhang N, Noble M, Mayer-Proschel M, et al. (2008) Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. J Biol 7: 24. DOI:10.1186/jbiol85