Monthly Archives: April 2011

Now is the Time to “Speak of Research”

Over the past decades we have heard many warnings about the need for scientists to engage with the public.  Unfortunately, the bulk of the scientific community has largely ignored such calls.

Fourteen years ago, in their book, “World apart: how the distance between science and journalism threatens america’s future”, Hartz and Chappell explained that  “at the heart of the matter is the value we [society] place on science itself.”    This is indeed what’s at stake.  Nothing more, nothing less.

Scientists must talk to the public because social policies need to be decided on the basis of rational grounds and facts, including issues ranging from climate change, to the goals of the space program, to the protection of endangered species, the use of embryonic stem cells, and the use of animals in research.

Many have warned that if the public and policymakers do not hear the voice of scientists, if they are not presented with the facts, it may only be a matter of time before a large segment of the public will be asking why are we doing (and why they are paying for) such work.   A recent poll by the Pew Research suggests that this might already be happening.

Society needs from the help and engagement of scientists to understand our work and its importance for future progress and advances.  The american public is, in general, ill equipped to grasp the nuance and significance of scientific developments on their own.  For example, only 25% of americans consider themselves sufficiently informed as to the “nature of scientific inquiry” to make judgements about reports they see in the media.

Our representatives have also repeatedly asked for scientists to participate more in public life.  Addressing a meeting of the American Association for the Advancement of Science (AAAS), Congressman Sherwood Boehlert told his audience that:

“Scientists should participate actively, even avidly, in policy debates. Indeed, both as educated citizens and as professionals with relevant knowledge, scientists ought to feel obligated to contribute to policy making in their communities, in the nation and even in the wider world”. 

At another meeting of AAAS, his congressional colleague John Porter offered the view that:

“Scientists are by every measure the most respected people in America. They are listened to. But if the public and policymakers never hear your voices, never see… science, never understand its methods, the chance of its being high on the list of national priorities will be very low. [...] You can sit on your fingers or you can go outside your comfort zone and get into the game and make a difference for science. Neither we, nor AAAS, nor any other group can do it all for you. Science needs you. Your country needs you. America needs you… fighting for science!”.

Indeed, it is time to go out of our comfort zone.   Granted — not all scientists are good public communicators, but they surely can learn to communicate effectively and, besides, the alternative is totally unacceptable.  A recent Editorial by Christopher Reddy in Science agrees:

“Communicating is risky, but not doing so is riskier. If scientists and journalists don’t try harder and make continual efforts to learn each other’s languages and gain confidence, knowledge will remain locked in laboratories, misunderstood, unused, or even worse, misused. When this happens, those who thirst for information are shortchanged, and the work of scientists becomes more of an interesting hobby than a critical endeavor of fundamental value to society.”   

Reddy goes on to suggests very specific ways in which universities can help scientists engage with journalists that deserve the attention from our institutions and press offices.

Much of the criticism of animal research is generated by a failure to understand the value of science in general, what the work actually entails, and how progress in some areas of medicine and basic science are critically dependent on animal research.

It is a scientists’ obligation to society to explain the importance of our work and our commitment to ethical standards.

Now is the time to “Speak of Research”.

Waking up the Neighbors: A Neighborhood Response to Animal Rights Extremism

In previous posts, we’ve highlighted revolting new tactics by AR extremists, including the targeting of students and young scientists. Some animal rights extremists envision a future where the nation’s brightest students and talented scientists must live in fear for the safety of themselves and their families.  As for what such war would look like, some of SR’s members have first-hand experience. Now, thanks to some outstanding reporting by Public Television in Southern California (KCET), the public has a chance to see how some scientists who seek to cure disease and end suffering are now the targets arson, assault, vandalism, death threats and stalking.  

The KCET segment exposes the elements of hate and violence in a movement that, paradoxically, believes itself to be based on compassion and kindness.  It makes the main goal of such activism clear: to intimidate, threaten and harass the victim.   As one of the neighbors justifiably asked these activists — “Why don’t you demonstrate at UCLA instead?”   Of course, the answer is obvious; it is easier for these terrorists to threaten families at their homes.   They are not attempting to “educate” anyone about their position.  They are simply trying to force their views on society by violence and threats.

Here’s that report:

Testing the Limits.

Despite their repetitive claims online that their message is welcomed by neighbors, the opposite is actually true. Those who live in proximity of researchers being targeted support their neighbors even though they are, themselves, negatively affected by the focused pickets. This was noted in a report on an animal rights demonstration on a LA activist website which described animal rights extremists being “met with irate neighbors at every visit”.

Recently, near the home of UCLA researcher Edythe London, signs appeared on lawns throughout the neighborhood, with residents trying to give the picketers a strong message. If the petty vandalism and theft of the signs by animal rights protesters is any cue, that message was received.

It isn’t surprising that the animal rights extremists are put out by the clear display of support for scientists by their neighbors, after all, a major objective of “home demonstrations” – aside from harassment and intimidation of targeted individuals and their families mentioned above – is to isolate scientists from their neighbors and turn their neighbors against them. The demonstrations against the UCLA scientists have clearly had the opposite effect, prompting neighbors to rally around the scientists and their families.

SR would like to thank KCET for its balanced look at this issue as the report highlights three important questions that we feel must be answered:

1. How can the topic of animals in research be rationally discussed in the current environment of hate, threats and violence?   How can anyone expect scientists to participate in such discussion if they stand to be targeted at their homes simply for speaking up their minds?

2. How can such a discussion take place when many of those opposed to the research are blind to the countless human and animal lives saved through highly-regulated animal studies?

3. Most importantly, in this toxic environment, how can we ensure continued health advancement when the scientists of tomorrow may become the targets of today?

We believe that the scientific community cannot wait for extremism to end before scientists can start to discuss animal research. We believe that it is no longer acceptable for the scientific community to leave the task of speaking up for science to a handful of brave individuals, we must do more to support and protect those who are targeted by extremists. The answer lies in a community response to extremism that fosters a culture of proactive public education and engagement. Waiting to be targeted before responding is no longer an option, and there are many ways in which students and scientists can discuss the vital role played by animal research in advancing medicine without taking risks, as our friend Scicurious points out in an excellent post on the Experimental Biology 2011 conference:

Many animal researchers are worried about becoming targets for threats and violence, but you don’t necessarily have to stand up and make yourself seen. You can work through your professional societies to talk to people in government. You can write letters to your own government representatives. You can INVITE those representatives into your labs, to see what you do and what it all means. You can go into classrooms and talk about your work, or bring the classrooms to you and show them. You could even write a blog post on the internet. By reposting, retweeting, and passing it on, you can spread the word about funding and the necessity of careful animal research. And if all that still seems too much, you can always start with your family and friends. Tell them about what you do. Many of them may not even know. And tell them what it’s all for, and what we’re going through because of it. Because in this case, when the data speaks in a language only experts can understand, scientists have to stand up and do the talking.”

These are great suggestions, though as the experience of scientists at UCLA shows, in addition to talking to family and friends, talking to your neighbors can yield great results.

Speaking of Research

Animal Rights to English Dictionary

Over our history as an organization, we’ve read a lot of activist portrayals of health research and the people who undertake it. We’ve been called murders and torturers. We’ve had our heads super-imposed over bloody scenes and yes (unsurprisingly) we’ve even been compared to Nazis. See Godwin’s Law.

However, if you are a long-time reader of this Web site, you’ve come to realize something. Activist portrayals of science research are often science fiction. For example: Activist groups frequently send mass mailings to supporters about “infant monkeys torn from their mothers’ wombs.” Real world translation: The babies were born via cesarean section, just like 1/3 of the U.S. population.

Activist groups also frequently use “creative” language to portray researchers and research centers as shadowy and secretive. When groups have “unearthed documents that illustrate abuse,” they actually requested and obtained public documents. Then, used their anti-research point-of-view to translate the records into wild exaggerations that bear little resemblance to the facts they were handed in the first place.

As a public service, and a perhaps a method for bridging the communication gap between activists and scientists, we would like to propose The Activist to English Dictionary.”

Try it out – go find some typical activist verbiage (you know where to find it!) …see if you can use the dictionary below – to decode it.

Also, all you aspiring “Websters” out there, we need your help. Please help us fill out the dictionary by adding your own definitions in our comments section:

Definitions

A

Alternatives = Equality between two more more tools that have superficial resemblance. Activist public usage: “There are plenty of alternatives to animal studies” Activist private usage: “Well…actually there are a small number of alternatives but we better not tell the public that animal research is still required…because that would hurt our fundraising efforts.”

Animals are starved = Controlled access to food or water for animals.

Animals are poisoned = Animals are given medications prior to FDA approval to ensure they are safe for human consumption and to make sure we give people and other animals the right dose once it is made available.

Animals are sliced open/mutilated/cut up/dissected = Animals undergo a common blood test or undergo surgery that makes use of the same sterile conditions and pain medications as used on humans.

Archaic = Time tested and proven Usage: Animal research is archaic/time tested and proven.

C

Cosmetic testing = cosmetic testing.  This should not be confused with health research aimed at ending suffering or preventing human or animal death.

K

Killed = humanely euthanized.

L

Locked up/imprisoned = Animals that live in captivity.

M

Medical expert  = A PeTA/PCRM-paid physician, normally with very limited exposure to research.

Monkeys are forcefully restrained = Monkeys are trained to sit in a chair and receive treats as positive reinforcement.

More and more companies are switching to non-animal tests = More and more companies are paying other companies to do their safety testing for them so they can say they don’t test on animals.

P

Painful = Painful…if the animals are not given painkillers…but they actually are.

“PETA/IDA/PVCRM urged xxx company/university”= PETA/IDA up Web-based email system and told supporters to hit a send button which resulted in 10,000 identical emails being sent to one person often not directly involved in the thing being protested.”

R

Research kills humans = Research saves lives.

S

Secret documents = Public records asked for and received.

Sexism and or racism = Sexism and or racism Usage:Sexism and or racism is unacceptable for anyone else but completely acceptable to our activist group because these offensive tactics are being employed in the name of animal rights!

W

We support good science = We support anything that does not involve the use of

animals in science even when proven animal research models have saved countless lives.  Usage: “We support 21st century science, such as the use of computer modeling, tissue samples, quantum- chaotic technologies, holographic nano-technology, and eco-bot halo-based nintendography.”

V

Vivisection = The use of the same methods used in human surgery in animals with the goal of advancing medical science and the well-being of humans and animals alike.

Regards

Speaking of Research

Obesity, Smoking and Addiction

Morbid obesity and cigarette smoking represent the two most substantial causes of preventable death in the Western world. According to recent estimates, about 1/3 of all adult Americans are morbidly obese (meaning that their excess of body weight is large enough that it causes illness or disability), and these numbers are increasing; approximately 15% of the American public smokes – though the proportion smoking  in many parts of  the developing world is much higher. The rates metabolic complications that correlate with obesity, including diabetes, are also on the rise. Because both obesity and smoking influence risk for cardiovascular disease, stroke and cancer (the three leading causes of death in the United States), smoking and obesity account for substantial disease burden, health care dollar expenditures and deaths. They cut many human lives short and exert a substantial impact our national economy.

So, why do so many people engage in over-eating and smoking, when it’s obvious that these behaviors are harmful? In the case of smoking, the nicotine content in a cigarette – coupled with its other ingredients – produces feelings of reward and relaxation that people find desirable. The high sugar and fat content of many of the food items readily available today do the same because they taste so good. Because they are such powerful rewards, these stimuli are sought out and consumed by people, though there are significant differences between individuals, but what is now causing great concern is the degree to which these behaviors are leading to a generation of health problems – inherited by those who haven’t even made these choices themselves. These inherited factors are not just genetic.

Exceptional new work from Oregon Health & Science University (OHSU) has now shown that monkey mothers who consume a diet rich in sugar and fat during pregnancy give birth to offspring that are themselves prone to acquiring excessive body fat, exhibit heightened anxiety responses and carry a host of changes in gene expression and brain chemistry that underlie these susceptibilities. In essence, mothers who eat an unhealthy diet influence the physiology of their offspring in ways that make them obesity prone. Kevin Grove, the OHSU researcher leading these studies, indicated that an unhealthydiet during pregnancy:

“is programming the [fetal] brain to also seek that high fat diet and those highly palatable diets later in life, which are going to make them at higher risk for obesity and diabetes…”

Similar results have been found for smoking; for example, studies in rats show that when a fetus is exposed to nicotine during gestation (as they are when pregnant women smoke), the resulting offspring is at higher risk of seeking out nicotine and developing a pattern of routine intake. In other words, in both cases, mothers – by engaging in excessive eating and/or smoking during pregnancy, affect the life-long pattern of behaviors in their children.

Once some (but not all!) individuals begin smoking or eating high sugar/fat foods, they experience progressive loss of control and an associated spiral into food and cigarette addiction. The hallmarks of this dependence include 1) unsuccessful attempts to quit or control the behavior, 2) continued engagement in the behavior despite knowledge of a problem caused by it and 3) giving up life activities previously enjoyed because of the behavior. Put differently, what makes an addiction what it is is the fact that individuals cannot voluntarily stop, reduce or control their food/cigarette consumption. Once again, research reveals that it is genetic factors that differentiate those that descend into addiction from those that are resistant to it.

Today, research in humans and animals is focused on the biological factors that cause the compulsive nature of addiction. Studies in rats have revealed that changes in the activity of a neurotransmitter called dopamine contribute to the emergence of food and drug addiction. Studies in monkeys are beginning to reveal how obesity and food addiction take hold. For example, the news program Nightline ran a profile of research going on at the Oregon National Primate Research Center at OHSU that addresses the biological origins and consequences of obesity caused by intake of high sugar and fat diets, coupled with relatively low activity levels. These studies are showing what genes, proteins and biological pathways contribute to obesity and help to explain why it is so difficult to escape. As stated in the program:

“The animals [at OHSU] may hold the answer to curing a health problem tied to many of the leading causes of death in the United States…”

Across this nation, there is scarcely a family that is not affected by the sickness and death caused by smoking and/or obesity. This includes scientists who study animals in order to find cures for these problems. A researcher at UCLA, Professor Edythe London, who has been ruthlessly targeted by opponents of animal research, described her commitment to solving the riddle of cigarette dependence in a 2007 OpEd entitled “Why I use animals in my research”.

“My personal connection to addiction is rooted in the untimely death of my father, who died of complications of nicotine dependence. My work on the neurobiology of addiction has spanned three decades of my life…. To me, nothing could be more important than solving the mysteries of addiction and learning how we can restore a person’s control over his or her own life. Addiction robs young people of their futures, destroys families and places a tremendous burden on society.”

For many who have a personal insight into the devastating effects of addictions like compulsive smoking and/or over-eating, the humane and regulated use of a small number of animals in order to prevent suffering in the future is justified. Though their loved ones have suffered and/or died, there is hope for others, and scientific progress aimed at accomplishing this will not stop, no matter how much the nature of addiction or the animal research aimed at ending it are misunderstand and misportrayed.

Regards

David Jentsch

Embracing the 3Rs

Guest post from Jayne Mackta, President of the New Jersey Association for Biomedical Research, and CEO of Global Research Education & Training, LLC

At NJABR’s recent Strategy Summit entitled Animal Research: Risks & Reality, keynote speaker Jerrold Tannenbaum cautioned the audience to be aware of shifts in language that have tremendous power to affect public perceptions and ultimately public policy. His focus on enrichment took me by surprise and got me thinking. He pointed out that when Russell and Burch introduced their now famous 3Rs in 1959, the principles of Replacement, Reduction and Refinement were strategies for minimizing pain and/or distress in laboratory animals.

Over the years, the research community has embraced the 3Rs, which are intrinsic to good science methodology. We are always seeking better, faster, more efficient ways to move the process forward, including seeking ways to replace animals, reduce the number of animals used, and refine techniques.

Enrichment is a form of Refinement, which is described in the New Guide as “modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress.” Note the expansion of the concept to animal well-being.

Enrichment itself has more to do with the animal’s environment where the emphasis is on promoting species-specific behaviors, which does affect well-being and implies minimizing or eliminating pain and distress. However, the focus on “providing animals with sensory and motor stimulation” and promoting “psychological well-being” represents quite a shift from the original meaning of the 3Rs and certainly ramps up the role of enrichment in the humane care of laboratory animals. As a community, we need to think about what we say we are doing and carefully watch our words. We struggle to equate the 3Rs with the term “alternatives” that is commonly understood to stand for efforts to replace animals. For some, replacement has become an end in itself. I think we must be careful not to let enrichment become just another weapon in the war of words to end animal research.

Regards

Jayne Mackta, Publisher
President & CEO, Global Research Education & Training, LLC (GR8
)

Would you like to make a guest post? Contact us.

Pro-Test’s Pycroft still Speaking Up

Five years ago, a sixteen year old led scientists, students and members of the public in the first ever rally to support biomedical research. Laurie Pycroft shot into the media limelight as the boy who dared to stand up to animal rights activists. The Pro-Test movement he begun has helped to shape the public attitudes towards animal research in Britain – bringing them firmly behind lifesaving research.

So where is Laurie now? The Independent recently caught up with the 21-year old Pycroft, who has become an undergraduate at Oxford with an aim to study neuroscience.  He notes that, in addition to an early natural inclination in that direction, his interaction with scientists for Pro-Test drew him to research over clinical practice.

Modest about his exceptional accomplishments as founder of Pro-Test, he has been influential across the pond in the US as well. Pro-Test has acted as a model to both Speaking of Research, and the Pro-Test for Science movement (which has done more to effectively replicate Pro-Test’s tactics). His sense of justice and courage to speak out in the face of external malice and internal depression serves as a role model to us all. Below, we can see Pycroft and SR founder, Tom Holder, speaking about why they felt animal research was such an important issue while helping to inform the public on Pro-Test’s five year anniversary.

A number of scientists and organizations here in the US have stepped up to speak the truth in answer to the misleading propaganda from animal rights groups.  And now, as has been widely reported, AR activists have explicitly set students in their sights, targeting them for their supposed vulnerability to manipulation.

Laurie Pycroft is Exhibit A for the error of this assertion.  He is one of a kind, but what we do need is for individuals of the academic community in their departments, at their universities, and with their societies to band together in order to support one another, and to get the word out to the public about the truth of the methods and importance of animals in responsible biomedical research.  This engagement is part of the responsibility of being a scientist.

Like Laurie, no doubt most researchers at least understand where many opponents are coming from:

“Some of them have an internally consistent intellectual argument,” he says. “There is a popular misconception that animal rights activists are all firebomb-throwing nuts, but a lot are very reasonable people. There is a very small minority, but a very vocal one, which is not. A lot of them are in jail and so that part of the debate has been closed down.”

Here in the US, we still have our work cut out for us to allay the ravages of extremism.

Other young adults moved to take action have received support from the Hayre Fellowship and the considerable expertise of the dedicated individuals at AMP.  There is still time to meet this year’s application deadline on May 20th 2011. Any student or young person with a desire to educate and an innovative idea for outreach is encouraged to apply.

Medical progress and researchers personally, owe a debt of gratitude to Laurie and others who have shown the way by their leadership.  His studies will bring many new challenges that all graduate students past and present can sympathize with (and that we often hold up as an excuse to neglect our outreach duties).  He will no doubt excel, and we welcome him into the field.

Regards,

Megan

Fish for Science

Back in February I wrote about the prominent  role of Zebrafish in the British Heart Foundation’s Mending Broken Hearts campaign, an initiative that not only highlighted fascinating developments in regenerative medicine but also the degree to which the public attitude towards animal research has shifted in the past decade.

One reason for the change in attitudes towards animal research in the UK has been an increasing willingness on the part of scientists to discuss their work with the public. Today I learned from our friends Understanding Animal Research (UAR) of a great example of  what public engagement is all about, and once again zebrafish are the stars of the show. UAR have awarded their very first Wednesday Winner award to the The MRC Centre for Developmental and Biomedical Genetics at the University of Sheffield for their new Fish for Science website.

The Fish for Scence website provides an excellent introduction to the role of zebrafish in biomedical research, including – amongst many topics discussed - why they’re used , what diseases are studied, and the techniques used to study them. They also have links to resources where more detailed information about the role of model organisms, and in particular zebrafish, in biomedical research.

It’s a website that should serve as an inspiration to any research laboratory that is considering how to develop its program of outreach activities and improve the public understanding of science, and a worthy Wednesday Winner!

Paul Browne

Fostering a community response to threats against future scientists

This past week, Negotiation is Over posted on its website encouragement for a new tactic against animal research—targeting university students who plan to enter the health sciences field.  NIO illustrates its proposed tactic by telling of its first “success” story:  the coercion of a Florida Atlantic University science student away from a research career.  What NIO fails to disclose is that this student’s public statement was made only after  an intense 24 hours of threatening emails, phone calls and other forms of harassment by the group and its leaders.

Speaking of Research has posted its response to NIO’s violent urgings.  We invite you to visit the blog and to share supportive comments for the student who was targeted.Speaking of Research, Americans for Medical Progress, and Pro-Test for Science are working together to provide individuals and institutions with information and guidance on equipping students and scientists of tomorrow with the skills they need to confront threats from animal rights activists/extremists.  Please contact us if you are a scientist, research advocate, or representative of a research institution who would like to receive this information.

The experts at our three research advocacy organizations are available to you for suggestions on how your organization can effectively support those who are studying for careers in the life sciences.  Our websites offer many information resources and ideas about ways to get involved in the kind of proactive public education and engagement that is essential to building public understanding of the vital role animal research plays in scientific and medical progress. Through a policy of openness about your research – and the role it plays in advncing medicine – you can build strong relationships with your community and local news media, and in doing so help ensure that you do not become a target for animal rights extremism.

Please join us in standing against this current threat and those who would stop vital animal research.

Americans for Medical Progress, Pro-Test for Science, and Speaking of Research

Here are a few general online resources.  Contact us for more to meet your specific needs:

AMP—Research Facts
AMP—Advocacy Materials
SR—AR Extremism
SR—Advocacy
SR—The UK Experience
Society for Neuroscience—Best Practices for Protecting Researchers and Research
AAALAC International—links on animal research
Understanding Animal Research-Researcher’s Guide to Communications