Tag Archives: NIH

Several Hundred Pro-Test for Science

On a beautiful sunny day in Los Angeles, Pro-Test for Science organizers arrived at the junction of Le Conte and Westwood, on the edge of the UCLA campus, with armfuls of placards in support of animal research. Within ten minutes every placard had found a new owner as hundreds of scientists, students and members of the public showed up to support the cause. Those gathering chatted together, sharing their reasons for attending the rally.

Marchers Gather

Marchers Gather at the edge of the UCLA campus

Those participating were not limited to the UCLA community. Faculty from University of Southern California, California Institute of Technology, and California State University – Los Angeles, all came out to demonstrate their support for lifesaving medical research using animals. Soon the chants began to ring out – “Penicillin? ANIMAL RESEARCH! Insulin? ANIMAL RESEARCH! Vaccines? ANIMAL RESEARCH! Anaesthetics? ANIMAL RESEARCH!” A short while later, when the crowd had swelled further, the rally set off towards the center of the UCLA campus.

The marchers begin to walk towards the center of the UCLA

"What do we need? ANIMAL RESEARCH! When do we need it? NOW"

The mood was one of excitement and passion. Those participating exchanged ideas for public outreach in the future – sharing the best of ways of explaining to the public the clear connection between animal research and medical benefits. The rally continued to snake along  Westwood and up towards Wilson Plaza.

Those at the front were unable to see the back of the rally!

"No more threats, no more fear. ANIMAL RESEARCH NEEDED HERE"

As the rally turned into Wilson Plaza, passing the top of Bruin Walk, hundreds of students turned their heads towards the march, many shouting words of encouragement or joining in the rally.

"Cures for cancer, what's the answer? ANIMAL RESEARCH! ANIMAL RESEARCH!"

Eventually the tail end of the rally reached the destination (some time after the front end due to the length), and Tom Holder brought the crowd together for a picture perfect moment of solidarity before shouting “What do we need?”. “Animal Research” replied the hundreds of voices in unison.

David Jentsch at the Pro-Test rally 2010

Prof. David Jentsch

Holder then introduced the first speaker, Prof. David Jentsch – founder of Pro-Test for Science and member of the Speaking of Research committee – who took the microphone to rapturous applause. David spoke of the progress of Pro-Test for Science, and the struggle against animal rights extremists in UCLA. He took the time to thank each of the individuals who had made the 2010 rally possible eliciting a cheer from the crowd as each name was called. Jentsch then passed over to Tom Holder, founder of Speaking of Research.

Tom Holder at the Pro-Test for Science Rally

Tom Holder

Holder thanked the crowd, insisting that UCLA were winning in their battle against extremists. However he warned the crowd against complacency – saying that public outreach was the only way to win this battle in the long run. Holder also announced the success of the Pro-Test Petition, which had gained 11,621 signatures over the previous year (including Nobel Prize Laureates, and every chancellor in the UC system, including UC President Mark Yudof). He finished by announcing the presentation of the signatures to Dr. Kevin Quinn,  Dr. Michael Steinmetz.

Dr. Kevin Quinn

Dr. Quinn, the Chief of Behavioural Science and Intergrative Neuroscience at the National Institute of Mental Health (NIMH), accepted one copy of the petition on behalf of NIMH. Quinn spoke of the important role that animal research has in our understanding of Mental Health problems:

Animal research conducted in a humane, ethical and responsible manner is absolutely critical … to understand, treat and cure mental disorders

.

Dr. Michael Steinmetz

Dr. Michael Steinmetz, program director of the National Eye Institute, talked of the medical breakthroughs in vision. He spoke particularly of Leber’s congenital amaurosis, a form of blindess which affects thousands of people across the United States. Through research in mice and then dogs (Briards), scientists found a way of inserting a gene into the eye through a virus, which could corect the problem.

“The National Eye Institute supports strongly the use of appropriate animal models in research, not just for the big clinical advances but for the many, many years of basic science that it takes to discover the underlying biological principles

Scott Waugh

Jentsch then returned to the stage to introduce UC Executive Vice-Chancellor, Scott Waugh. Waugh offered his continued support to researchers at UCLA, mentioning that the Pro-Test for Science movement has played an important role in bolstering support for research. He congratulated Jentsch and Ringach for organizing the February pabel debate, explaining that “violence, threats and other criminal activity are never a viable alternative to dialogue”.

Jentsch and Holder finished the rally by talking of the importance of continued education and outreach.

They're Pro-Test. Are you?

Pro-Test for Science – Thursday April 8th 2010 – Stand up for Science

Press release:                                                                03/04/2010

Promoting Science and Rejecting Extremism

In 2009, Pro-Test for Science held an historic rally on the UCLA campus; bringing over 700 people onto the streets in support of the scientists and researchers who carry out lifesaving medical research using laboratory animals. Such research continues to advance scientific knowledge and plays a vital role in the development of innovative treatments for human disease. However, animal rights extremists have continued to escalate their threats against researchers and their families.

On Thursday April 8th Pro-Test for Science will respond by rallying students, scientists and members of the public to support the cause of medical science. We call on the community to stand together against the recent tide of animal rights activism which has worked to misrepresent research and coerce those that carry it out.

David Jentsch, founder of Pro-Test for Science, said:

The scientific community has joined together to push back against those who seek to stall advances in biomedicine. Never before has it been more important to continue these efforts so that humane biomedical research can continue unhindered by the misguided threats of a minority who oppose it.

This rally, on the UCLA campus seeks to:

  • Communicate a better understanding of animal research to the public, its importance  to medical progress, and what we all stand to lose if such work were to stop
  • Celebrate the successes of animal research in the development of treatments for disease, new diagnostic procedures/instruments, and surgical techniques.
  • Defend the rights of researchers to pursue their work free from harassment and intimidation.

The rally will begin on Thursday April 8th at 11:30 AM, on the north-east corner of Westwood Blvd. and Le Conte Ave., which will be followed by a march to Wilson Plaza, where speakers include UCLA Executive Vice Chancellor Scott Waugh and Dr. Kevin Quinn from the National Institute of Mental Health.

Please check www.speakingofresearch.com and www.pro-test-for-science.org regularly for updates and further communications. For further information contact:

David Jentsch – j.david.jentsch@gmail.com – +1 310 825 8258

Tom Holder – tom@speakingofresearch.com – +1 310 498 0881

Notes to Editors:

  1. The rally will take place from 11:30am, Thurday April 8th 2010 on the north-east corner of Westwood Blvd and Le Conte Ave.
  2. Further speakers are to be confirmed
  3. Report of the 2009 rally:  http://speakingofresearch.com/get-involved/ucla-pro-test/ http://www.nbclosangeles.com/news/local-beat/West-Side-Story-Scientists-Activists-Face-Off-at-UCLA.html
  4. Pro-test for Science was formed in March 2009 by David Jentsch:
    See www.pro-test-for-science.org

Standing Together: Widespread Support for OSU and its Research

The controversy over Oklahoma State University’s President Burns Hargisrecent decision to cancel a major research project has attracted international attention.  What has emerged is not yet a reversal of a bad decision, but evidence of far-reaching support for the OSU scientists who courageously spoke out and, more generally, for the responsible use of animals in lifesaving biomedical research.  The outpouring of concern over Hargis’ errors in decision-making has sent a clear message that such actions will be met with broad public attention and censure by those who support scientific progress.  If Hargis and OSU’s administration believed that their interference with an approved and funded biodefense research program could be accomplished without notice, they were proved wrong. This episode will stand as an example of public condemnation of institutions and administrations that cede to animal activism, whether it is from the pressure of donors or from threats of violence either real or anticipated. Taking anything less than a strong stand against the fear that animal activists seek to inspire is to take the wrong path. It leads away from scientific progress and away from democratic process.

A fringe contingent of animal activists would like for this case to represent the power of what they call direct action, campaigns of violence, harassment, and fear against those engaged in animal research.  And it has already been cited <Warning: Animal Extremist Site> in their calls <Warning: Animal Extremist Site> for what can only be called terrorism.  This is not a surprising result. It should have been anticipated by Hargis and should be by others who would bow to animal activists. For the vast majority of those concerned, however, this episode illustrates something more important. It highlights the growing resolve, support, and consensus for vocal and visible support of animal research, support that extends beyond the academic and scientific community to the greater public who benefit from progress in increasing basic understanding of health and from medical advancements that are achieved through animal research.

It is not difficult to appreciate Hargis’ fear of animal activism.  Many of us, particularly– but not only– those of us engaged in primate research, have been the targets of actions that are designed to induce fear by those who are unable to achieve their goals through civil means. These experiences are intended to be disturbing. Without the support of our institutions and others, the actions of animal activists pose challenges that can be difficult to overcome. Ending fear campaigns is an essential goal. What is also essential is that individual scientists and institutions realize that silence ultimately does little to protect against animal activism and that no one has to stand alone against it.

Burns Hargis

Speaking out in support of animal research has occurred in many places and by many individuals. In the U.K., Pro-Test sets a remarkable example of the power of taking a strong and public stand on the importance of responsible use of animals in lifesaving research.  Building on Pro-Test’s success, Tom Holder founded Speaking of Research in the U.S. and energized the growing coalition of scientists, students, and others who speak out and stand publicly for scientific progress and animal research. In California, where scientists have endured the worst of animal activism, UCLA scientists Drs. J. David Jentsch, Dario Ringach, Lynn Fairbanks and others founded Pro-Test for Science and demonstrated the surge of public support for its scientists and animal research programs.  With Americans for Medical Progress, Speaking of Research and UCLA Pro-Test initiated the Pro-Test Petition in April. Over 11,000 signatories to date have affirmed the value of animal research and the importance of defending it.  These efforts join the many local and national programs that engage the public in dialogue about the role of nonhuman animals in ethical and humane behavioral and biomedical research. Together they show the strength of a community that can effectively challenge animal activism and demonstrate the importance of animal research to the public.

Speaking of Research provides a summary of the coverage of the OSU situation here and encourages you to share it with others who are interested in following this important discussion. The outcome has implications well beyond primate research, and will certainly help to shape the future of animal research in the US and around the world.

Allyson J. Bennett, Ph.D.

Speaking of Research

The views expressed on this blog post are mine alone and do not necessarily reflect the views of my employer, Wake Forest University Health Sciences.

Summary of news and opinion:

11/30/09:   In the Daily Oklahoman reporter Susan Simpson breaks news of OSU President Hargis’ decision to cancel a primate research project.  Anthrax study rejected by OSU:  Euthanasia of primates may be to blame for decision to cancel veterinary school project.
11/30/09:  KOCO 5 Oklahoma City. OSU Turns Down Anthrax Study: President Against Animal Testing
11/30/09:   Science bloggers quickly picked up the story. In her post, Ongoing witch-hunt against Oklahoma scientists, Part Deux, Science Blog’s ERV called it:  “Quite possibly one of the weirdest things I have ever witnessed in my scientific career– The president of Oklahoma State University has ‘forbidden’ an ethics panel approved, NIH funded research project on ‘his’ campus.”
11/30/09:    Science Blogs, Drug Monkey. OSU President Blocks NIH Funded Science to Appease Philanthropist.
12/01/09:  Animal activist Madeleine Pickens, wife of wealthy donor T. Boone Pickens, praised Hargis’ decision on her website. Re-posting a story from DVM Magazine, Pickens places her commendation in the article’s title, adding to it “Kudos for a Great Decision!”
12/01/09:  Tulsa World. Editorial.  Anthrax fiat: Science should guide research.
12/01/09:  The Scientist. Jef Akst. School halts baboon anthrax study.
12/02/09:  Speaking of Research.  Oklahoma University President Interferes with Federally Funded Health Research.
12/02/09:  Federation of American Societies for Experimental Biology (FASEB) releases a statement in support of animal research.
12/02/09:  Primate Freedom. Rick Bogle. Panties Bunched Up by Baboons. <Warning: Animal Extremist Site>
12/02/09:  Science Insider. Greg Miller. Why Did Oklahoma State Cancel Anthrax Research Project?
12/03/09:  Science Blogs, Scicurious at Neurotopia. An Open Letter to OSU.
12/04/09:  Daily Oklahoman, op-ed by OSU President Hargis OSU’s best interests at center of decision.
12/04/09:  Drug Monkey. OSU President Responds to Critics, Fails to Explain Anything.
12/07/09:  Speaking of Research, Dr. Allyson J. Bennett. OSU President Yet to Explain Decision to Cancel Primate Project.
12/07/09:  Nature News.  Brendan Borrel. Primate study halted by US university: Officials fear violent reprisals from a reinvigorated animal-rights movement.
12/08/09:  Discover Magazine. University, Fearing Animal-Rights Violence, Axes Baboon Study.
12/08/09:  The New Scientist. Andy Coghlan. Anthrax study on baboons axed by university president.
12/08/09:  AgrOpinion. Daryl and Jody Donohue. Did Oklahoma State Bow to Activists?
12/09/09:  Daily Oklahoman. “OSU chief Burns Hargis discusses research decision: Burns Hargis had ended a project that would have resulted in euthanizing baboons.” Hargis says his decision was based on “confidential factors.”
12/09/09:  Science Blog’s ERV posts The Ballad of Leeroy Hargis in response to OSU President’s admission that he made a “rookie error” in his decision-making.
12/09/09:  Minneapolis Post. Sharon Schmickle. Animal rights vs research: OSU halts anthrax study.
12/09/09:  Advocates for Agriculture repost Minneapolis Post story, add commentary from rancher perspective OSU Bows to Activists Threat.
12/09:09:   Inside Higher Ed.  Scott Jaschik. Euthanized Research Project.
12/10/09:   Speaking of Research.  Dr. David P. Friedman.  University Leadership and Animal Research: A Dean’s Perspective.
12/10/09:  Newsweek.  The Primate Problem:  OSU has halted a baboon study, infuriating scientists. Are animal-rights extremists finally getting their way?
12/10/09:  Nature. Editorial. A slippery slope: Animal research policies should be guided by moral consensus, not by arbitrary decisions. Nature 462, 699 (10 December 2009) | doi:10.1038/462699b; Published online 9 December 2009.
12/10/09:  Negotiation is Over.  Direct Action Gets the Goods…Pre-emptively. <Warning: Animal Extremist Site>
12/11/09:  Science. Greg Miller. Animal Research: Rejection of Anthrax Study Kicks Up a Dust Storm in Oklahoma. Science 11 December 2009: Vol. 326. no. 5959, p. 1464. DOI: 10.1126/science.326.5959.1464

OSU President Yet to Explain Decision to Cancel Primate Project

The rapidly growing controversy over Oklahoma State University’s President Burns Hargis decision to cancel a research project has attracted national attention for a number of reasons.  The November 30th Daily Oklahoman report on Hargis’ decision has ignited discussion and calls for both reversal of the decision and accountability in addressing the many questions that have been raised about decision-making at OSU. Science bloggers—including ERV, Drug Monkey, and Scicurious at Neurotopia– and commentary by their readers highlight the range and type of concern. Speaking of Research provided analysis that places the single research project into the broader context of OSU’s efforts to grow its research program over the past several years. Science magazine’s Greg Miller reported on the story in Science Insider. On December 2nd, the Federation of American Societies for Experimental Biology, the largest coalition of biomedical research associations in the United States, representing 22 scientific societies and more than 90,000 members, released a statement:

The Federation of American Societies for Experimental Biology (FASEB) finds the reports of the cancellation of an anthrax study involving nonhuman primates at Oklahoma State University (OSU) to be troubling. ‘We are concerned that this undercuts the role of the Institutional Animal Care and Use Committee (IACUC), and blocks the use of appropriate animal models in crucial biodefense research,’ said FASEB President, Mark O. Lively, Ph.D.

Animal activists groups have also joined in.  Hargis has been praised for his action by Madeleine Pickens, wife of wealthy donor T. Boone Pickens, on her website. Re-posting a story from DVM Magazine, Pickens places her commendation in the article’s title, adding to it “Kudos for a Great Decision!” and underscores the statement within:

a ‘generous benefactor’ to OSU and her ties to the Humane Society of the United States may have played a role in the termination of the project.

Speaking of Research encourages interest and public dialogue about the role of responsible use of animals in research.  We also call for attention to the major issues raised by this situation, which are:  Who should be empowered to interfere with funded research, and by what process should this occur?

Disagreement about the use of animals in research, about specific procedures, allocation of resources, and national funding priorities are all issues that merit national, public dialogue with an engaged citizenry.  These issues should not, however, be settled by the actions of a single individual who seeks to overturn the decisions and interfere with the processes of the many that are involved in distribution of federal and state monies, scientific review, and institutional oversight of research.

On Friday, an opinion piece by Hargis, formerly a businessman, appeared in the local newspaper and appeared to have the goal of reassuring Oklahomans and others that his decision was in the best interest of his university. The piece is titled “OSU’s best interests at center of decision.”  Others have provided analysis of potential problems with his statement and have called for him to address questions that still remain unanswered. Speaking of Research agrees that there are many questions that Hargis has dodged in his statement and we will return to more detailed analysis of those in a subsequent post if they remain unresolved.

Of immediate concern however, is the fact that Hargis appears to feel confident that he is not only competent to make decisions about scientific research, but is also correct to do so based upon consideration of narrow interests.  We disagree.  Hargis is interfering with research that is part of a much larger family of work that addresses essential questions with relevance to human health. The research at the center of this controversy is a line of work undertaken because it reflects research priorities identified not only by the scientific community, but by state and federal agencies.

The line of research that Hargis is interfering with is aimed at evaluation and development better vaccines to protect our troops and our citizens against bioterrorist agents.  Although Hargis is attempting to focus attention on a single project, the implications of his decision-making about this project are much broader.  Allowed to stand, the consequences of this decision will go well beyond the local community and have the potential to influence the course of bioterrorism research.

It is possible that Hargis does not understand the process by which decisions are made about dedicating resources and funds for research by federal and state agencies. It is also possible that he does not understand the process that moves science and health research forward.  Scientific progress and advancements in medicine most often depends upon interconnection between research projects, collaboration between scientists at different institutions, and sharing of resources and facilities.  The project at OSU appears to exemplify this, with collaboration and sharing of resources and facilities between scientists at OSU and other institutions.  Rather than recognize this strength, Hargis has leveraged it to explain his action, saying:  “The financial impact to OSU would have been minor and OSU’s role would have been limited…”

Burns Hargis

It is hard to believe that Oklahoma’s citizens and elected officials would support Hargis’ decision to act according to such narrow interests.  Although Hargis is charged only with leading OSU, it would seem that he should also be held responsible for serious consideration of how his actions affect the broader public, including the state and federal interests that underlie funding for OSU’s facilities.

Clarification and explanation of many aspects of the OSU situation remain to be provided by OSU’s administration.  We hope that this clarification is forthcoming and that Hargis will make himself available for an open public discussion of the situation rather than issuing statements or op-ed pieces with scant information.  Thus far, to our knowledge, Hargis has failed to hold an open press conference, nor have state officials or regents addressed the issue publicly.

Of the many questions that remain to be addressed, one is whether Hargis has used his office to subvert public processes in an attempt to support the agenda of animal activists. In his op-ed, Hargis appears to deny animal activist influence in his decision:

It has been suggested that this decision was reached arbitrarily and it was influenced by animal rights activists as well as a donor. Nothing could be further from the truth.

The appearance of the congratulatory post on activist Madeleine Picken’s website, along with a previous controversy involving OSU and Pickens, conveys, however, the impression that Hargis’ attention is to wealthy donors rather than to national priorities for public health research.  Applauding Hargis’ action is, in many ways, applauding a course of action that is in opposition to democratic process.

If Hargis wants to make his office the arena for both dialogue and debate about animal research, Speaking of Research will applaud his desire to engage in an essential discussion.  What should be understood by Hargis and others is that interfering in a line of research already endorsed at federal, state, and local levels is an action that is deeply troubling and will receive widespread attention until it is reversed. Hargis is presumably accountable to the state legislature and citizens of Oklahoma.  If he is unwilling to provide clarification about this situation in a manner that addresses the many questions raised, we ask that others step in to do so.  Contact information for state officials is below.

Allyson J. Bennett, Ph.D.

Speaking of Research

The views expressed on this blog post are mine alone and do not necessarily reflect the views of my employer, Wake Forest University Health Sciences.

Oklahoma’s two Senators are:
Tom Coburn, M.D. http://coburn.senate.gov/public/
James M. Inhofe http://inhofe.senate.gov/public/
and their Congressional Representatives are:
Dan Boren  http://boren.house.gov/
Tom Cole  http://www.cole.house.gov/
Mary Fallin  http://fallin.house.gov/index.html
Frank Lucas  http://www.house.gov/lucas/
John Sullivan http://sullivan.house.gov/
The appropriate people to contact in the Oklahoma State legislature are
probably the members of the Higher Education and Public health
committees in the House of Representatives
http://www.okhouse.gov/Committees/Comm_CommitteeMembers.aspx?CommitteeID=70&SubcommitteeID=0
http://www.okhouse.gov/Committees/Comm_CommitteeMembers.aspx?CommitteeID=74&SubcommitteeID=0
and the Public Safety and homeland Security committee in the state
Senate, who can be found starting from.
http://www.lsb.state.ok.us/

Oklahoma University President Interferes with Federally Funded Health Research

Call for Support of Oklahoma Scientists and Research Programs

Speaking of Research, along with scientists and others across the country, were appalled to learn yesterday that Oklahoma State University’s President cancelled a research project for which his university had already accepted federal funding and which had been approved at all levels of review by both the federal funding agency, the National Institutes of Health, and the university’s own Institutional Animal Care and Use Committee.  This grave threat to the academic freedom of researchers in Oklahoma should be a wake up call to investigators around the world.  Reported in the Daily Oklahoman newspaper yesterday by Susan Simpson:

“Veterinary medicine researchers were told by e-mail last month that OSU President Burns Hargis wouldn’t allow the National Institutes of Health-funded project, even though an internal faculty committee had spent more than a year setting out protocol for the care and use of the primates. Veterinary scientists say the decision was sudden and arbitrary, and now they fear the president may call for ending other projects involving animal research.”

All evidence appears to support the conclusion that OSU’s administrative decision was made unilaterally by the President and, most likely, without consultation of the faculty, scientists, or the broad community.  A university spokesman, Gary Shutt, explained the administrative reasoning as follows:

“this research was not in the best interest of the university. The testing of lethal pathogens on primates would be a new area for OSU that is controversial and is outside our current research programs.”

It may be the case that OSU’s administration is afraid to support what is perceives as controversial or novel research; however, as a growing number of people have pointed out, it seems more likely that Hargis may have been influenced by an animal activist agenda and the opinions of a wealthy donor.  Two science blogs responding to yesterday’s story provide more information and insightful commentary. In a post titled “OSU President Blocks NIH-funded Science to Appease Philanthropist,” science blogger Drug Monkey summarizes:

“OSU, you may recall, already caved to the threats of one Madeleine Pickens, wife of gazillionaire T. Boone Pickens. Earlier in the year she objected to the OSU Vet school using dogs for research and training and held a $5M donation to OSU over their heads. Now, the link to her own site is the best I could do for confirming the fact that OSU actually responded to her extortion (yes, I realize they were under no obligation to accept her money; this is still extortion) but it certainly sets a tone.

This recent move suggests that the OSU did indeed cave to Ms. Pickens’ demands. Furthermore it confirms exactly why it is inadvisable to accede to terrorist demands- it just encourages them.”

Faculty at OSU, speaking out in the local newspaper, also expressed belief that Hargis’ decision was influenced by a political animal rights agenda:  “Veterinary scientist Richard Eberle said the faculty believes Hargis’ ruling was influenced by an animal rights advocate or other organization. He fears the decision will jeopardize future projects as well.”

Hargis

They also point out that the research is part of a much larger investment made by the state of Oklahoma and other funding sources that contributed over the past several years to construct state-of-the-art biosafety laboratory facilities at OSU.  The facility was built with the express intent of supporting nonhuman primate research and under the condition that it would also be accessible to researchers at other Oklahoma institutions. Veterinary doctor Michael Davis said in yesterday’s newspaper account:  “The project was to be conducted in a multimillion dollar lab at OSU designed for research on bioterrorism agents. Davis said administrators have known for years that primates would be used in research in the new lab.”

An October 2006 press release from OSU announced the new facility and “recognized the Presbyterian Health Foundation for its investment in veterinary medical research at OSU. The result of a partnership marked by the foundation’s $1 million gift to the veterinary center, the facility greatly expands capabilities for biodefense and emerging infectious disease research.”

In the same release, Dr. Michael Lorenz, professor and dean of the veterinary center, explains the importance of the facility and research:

“We believe there is but one medicine, and it is comparative,” Lorenz said. “We offer the biomedical community in Oklahoma a cadre of comparative medical scientists capable of addressing a variety of important medical diseases. The zoonotic diseases and emerging infectious diseases are increasingly important to both animal and human health, and this facility greatly enhances our ability to study the pathogenesis, diagnosis, treatment and prevention of these agents.”

According to a report made to the Oklahoma State University/A&M Board of Regents in Stillwater, Oklahoma in July of 2007 by OSU’s Stephen W.S. McKeever, vice president for research and technology transfer, and titled “State of Research 2007: OSU growing a national, competitive research program:”

“OSU has the highest concentration of Biosafety Labs in Oklahoma (13) and state-of-the-art labs located in Venture I at the Oklahoma Technology & Research Park. OSRHE funds supported 21 new faculty in physics, microbiology, electrical engineering and chemical engineering. The National Institutes of Health awarded up to $40M task funding to the College of Veterinary Medicine as a result of these world-class facilities (approximately $8M to date).”

The report concludes with:  “Bottomline: Investment in research pays off-educationally for students, financially for the university and economically for the state.”

Hargis’ decision to cancel a research project at this time–after accepting the funding for a multimillion dollar construction project and federal research funding—should merit more explanation to his faculty, his community, and the public that supports federal research funding than the explanation he offered yesterday via his spokesperson.

According to the U.S. government website that tracks federal research funding, the state of Oklahoma received $68,050,369 from the National Institutes of Health in 2008.

It is unclear whether the Oklahoma’s board of regents has full knowledge of Hargis’ decision and whether it is supportive of this kind of behavior.  We hope that the regents will speak out on this issue and clarify their position.  Furthermore, the regents could introduce a new policy whereby in cases the where university administration wishes to change its stance on some types of animal research it should do so only after full consultation with the departments and individual scientists who would be affected, and such changes should only apply to project applications initiated after the change in policy has been announced.

OSU and its partner institutions, including other universities and medical research facilities in Oklahoma and beyond, are home to scientific resources and leading scientists that are important to many areas of research aimed at improving human and animal health.  We hope that the scientists in Oklahoma who now face this attack on their work receive visible, vocal, and immediate support from their local community—including other faculty, but also students, the public, and administrators.

Certainly, it is hard to believe that the citizens, elected officials, and others in Oklahoma would be untroubled by what appears to be an open threat to the integrity and strength of their university system.

Support from the broad scientific community in the US and growing media coverage also means that the decisions and actions taken by OSU and its President will receive attention nationally from many scientists and others who are concerned not only about biomedical research, but also about academic freedom and our nation’s commitment to science.  The manner in which this case is handled has implications that go well beyond Oklahoma, but unfortunately President Hargis’ actions have already drawn negative attention to the university and have the potential for long-lasting negative consequences to its reputation. As one of its faculty pointed out in the Oklahoma newspaper:

“OSU is now seen by researchers at other institutions as an unreliable research partner and afraid of animal rights demonstrators,” Eberle said. “It is sad that such a golden opportunity for OSU and the state of Oklahoma to attain national recognition has been missed as the result of a single individual’s decision.”

Finally, the events that transpired at OSU highlight the need to ensure that investigators hired to conduct biomedical research with animals have an assurance that they will be supported by their institutions and its officials.  One obvious problem is that university administrators change over time and, what one administrator considers acceptable research may not be viewed as such by another.   The only viable solution to this problem seems to be some type of enforcement from NIH.  While NIH cannot dictate the policies of each institution regarding animal research, it could certainly ask from each institution for an assurance that once the IACUC has approved a protocol and a grant has been awarded, that the institution will support the research throughout its funding period.  Such an assurance could be made part of the same compliance assurance filed by each institution with NIH in order to obtain funds for animal research. Failure to comply with the assurance could result in similar penalties as those incurred in violating compliance issues, including the potential loss of future funding and the renewal of existing projects.   Unfortunately, it seems that only when an institution sees risking their entire biomedical research enterprise that they will decide to defend it as a whole.

Speaking of Research calls on all those who support OSU’s scientists and the broader community engaged in collaborative research with OSU to offer their support and encouragement for a rapid resolution of this problem.  Contact information for President Hargis, the Board of Regents governing OSU, and Oklahoma’s elected official are provided below.

Speaking of Research

CURRENT MEMBERSHIP of the BOARD OF REGENTS for the
OKLAHOMA AGRICULTURAL AND MECHANICAL COLLEGES

Mr. Calvin J. Anthony (Stillwater) – Chairman
Mr. Greg L. Massey (Durant) – Vice Chairman
Mr. Fred L. Boettcher (Ponca City)
Mr. Douglas E. Burns (Norman)
Mr. Joe D. Hall (Elk City)
Mr. Jay L. Helm (Tulsa)
Mr. Andy Lester (Edmond)
Mr. Terry L. Peach (Mooreland)
Mrs. Lou Watkins (Stillwater)

EXECUTIVE SECRETARY – Dr. W. Douglas Wilson

OSU/A&M Board of Regents | 2800 N. Lincoln Boulevard | Oklahoma City, OK 73105
Voice: 405-521-2411 | FAX: 405-521-2501 | E-mail: board@okstate.edu

Open Letter to Michael Budkie

Michael Budkie

Michael Budkie

On June 1, 2009, animal rights activist, Michael Budkie, submitted a letter of complaint (AR Website) to the United States Department of Agriculture (USDA), with the charge that scientists are performing duplicative research.  Mr. Budkie’s complaint was based upon his own analysis of the publicly available information about research funded by the National Eye Institute, a division of the National Institutes of Health. Budkie’s complaint, related information, and press releases are posted on the website of Stop Animal Exploitation Now (AR Website)(S.A.E.N.).  We feel that it is essential to point out that his analysis, through omitting critical details, presents a remarkable illustration not only of bias, but also a fundamental misunderstanding of the scientific process. Here, we identify his omissions and mis-representations and request a response to our challenges.

An Open Letter to Michael Budkie, Animal Health Technician, Stop Animal Exploitation Now

re:  Research industry next to meltdown, charges watchdog; urges federal probe after study shows fraud in 26 laboratories, including Harvard, University of California

Dear Mr. Budkie,

You have recently requested that the federal government investigate what you represented as wasteful spending on health-related research. You believe you have identified an enormous problem with duplication of research, based on your perusal of some of the grant applications that the National Institutes of Health have funded over the past five years.

In an effort to understand your position, we have read your recent complaint to the USDA and looked closely at what you offer as supportive documentation.  Here are some of our reflections.

Your spreadsheet shows that scientists engaged in research often use some of the same tools and methods to conduct their work.  You are correct. The conclusion that their efforts duplicate one another, using more animals than is minimally required to advance science, is not.

Information on the approaches used to conduct a research project is found in the “Methods Section” of a grant application or manuscript. Unfortunately, you appear to have missed the pages of text that came before the Methods; in these sections, you find the nature of the problem being addressed by each research proposal. It goes without saying that – with respect to human health – there are lots of problems needing to be addressed, so part of what is discussed in a grant first is which ones are important and why. These sections also delineate what is already known and what isn’t.  All of these points are addressed in grant applications and journal articles. They are found under sections such as Introduction, Specific Aims, Background and Preliminary Data. Together, all of those parts give the context and rationale for why each particular research project is needed and why the specific methods chosen are the best possible means of addressing the identified problem.  According to your letter and spreadsheet it would seem that you have limited yourself to the methods used in the research, which does little to explain its context.

What you claim is that your “analysis” demonstrates that a large number of scientists are doing the same study (in some cases, over and over again for years). Essentially, you figure that if scientists are using the same kind of animals, the same kind of methods and the same kind of equipment, they must all be doing the same experiment.  In turn, you suggest that the government is paying for the same experiment many times. You conclude that this is needless duplication—a waste of animals, time, and money. However, once again, you misunderstand, or misrepresent, that each of these projects is addressing very different problems, each with independent implications for our understanding of human biology. Indeed, to ignore the question and focus on the similarities of methods is kind of like saying that two farmers, both of whom are planting seeds in soil and using the same kind of tractor, are growing the same crop to feed the same family.

If ten scientists all use microscopes in their research and look at cells from the same kind of animal, are they all doing the same research?  Maybe. Or perhaps one is looking at cells from breast tissue to determine whether they are cancerous, while another is looking at cells from brain tissue to determine whether they have abnormalities associated with Alzheimer’s disease.

Or maybe they are both looking at cells from breast tissue to determine whether it is cancerous. One is comparing the cells of an animal exposed to environmental toxins to cells from an animal that has not been exposed. That scientist’s goal is to learn how to make environments safer and reduce the risk of breast cancer.  Meanwhile, the other scientist is evaluating the cells of an animal who received an experimental drug to treat breast cancer. This scientist’s goal is to determine whether a new drug, one that might be effective in treating breast cancer, is effective and safe.

Are these two scientists—both working with the same kind of animal, using some of the same tools and techniques, same type of cells, and studying the same disease—doing duplicative research?  Is it the “same” experiment?  Should we choose to do one and not the other because it would be wasteful to have two studies that might help prevent and treat breast cancer?

You must appreciate that while the scientific method requires replication of findings to assess their reliability, scientists cannot succeed in making breakthroughs that improve human and animal health if they simply duplicate what others have done.  Furthermore, in exercising its responsibility for federal funds, the NIH will not provide support for grants that are not advancing research boundaries. What the concerned reader should know is that each of the grants listed by Budkie is among less than 10% of all applications that underwent rigorous review by a panel of scientists who made a recommendation to professional program officers at the NIH who are responsible for distributing tax-payer money effectively and equitably across scientific projects.

The scientific projects funded by the grants listed in your spreadsheet relate to one another as must all good science, but they certainly do not duplicate one another.  For example, different grants support research on different parts of the visual system and different brain regions—all of which are important to vision.  The diverse grants support research on basic visual processes, interactions of vision with other senses, mechanisms of visual attention, decision making, how movements of the eyes are controlled and how these processes affect vision.  Many grants support basic research on fundamental processes, while others fund work focusing on clinical disorders such as amblyopia and strabismus.

If you add a couple of columns to your table – ones that focus on the problem that the research addresses, you would not only provide a more honest portrayal of the science you criticize, but you would also provide the basis for reasonable discussion.  As it stands, your poorly-formulated complaints, self-referential, hyperbolic media releases and selective presentation of information all start to suggest that it is your industry trying to avoid meltdown, that is being rather too creative with the information you have at your disposal.

Yours Sincerely,

Speaking of Research