Herding Hemmingway’s Cats: Book review

What can cats with six toes, flies with wimpy testis, fish with hips, and mice with socks tell us about how our genes work? Turns out, they – together with a cast of characters ranging from bacteria to our own species – can tell us quite a lot. In Herding Hemmingway’s Cats: Understanding how our … Continue reading Herding Hemmingway’s Cats: Book review

Open Letter to the Australian Senate regarding a proposed bill to ban the import of primates

The following letter has been sent to the Committee Secretary of the Senate Standing Committees on Environment and Communications regarding the Environment Protection and Biodiversity Conservation Amendment (Prohibition of Live Imports of Primates for Research) Bill 2015. This proposed bill would ban the Australian research community from importing primates for use in biomedical research. The following … Continue reading Open Letter to the Australian Senate regarding a proposed bill to ban the import of primates

Cotton Rats, Calves and Clinical Trials: New RSV vaccine shows great promise.

Respiratory syncytial virus (RSV) affects almost two-thirds of babies in their first year of life, and is a leading cause of bronchiolitis and severe respiratory disease in infants, young children, immunocompromised individuals, and the elderly throughout the world. It is a major cause of hospital admission for infants, and results in up to 200,000 deaths … Continue reading Cotton Rats, Calves and Clinical Trials: New RSV vaccine shows great promise.

Clinical trial success for Cystic Fibrosis gene therapy: built on animal research

This morning the Cystic Fibrosis Gene Therapy Consortium (GTC) announced the results of clinical trial in 140 patients with cystic fibrosis, which demonstrate the potential for gene therapy to slow – and potentially halt – the decline of lung function in people with the disorder. It is a success that is built on 25 years … Continue reading Clinical trial success for Cystic Fibrosis gene therapy: built on animal research

European Commission rejects Stop Vivisection Initiative

Today the European Commission rejected the Stop Vivisection Initiative that sought to repeal European Directive 2010/63/EU on the protection of animals used for scientific purposes and ban animal research in the EU. Today, there are effective treatments for many infectious diseases, some forms of cancer, and several chronic diseases such as diabetes. These advancements would … Continue reading European Commission rejects Stop Vivisection Initiative

Lung cancer immunotherapy, from PD-1 knockout mice to clinical trials

This morning many news outlets, including the BBC, covered a very promising development in lung cancer therapy; the successful clinical trial of the cancer immunotherapy Nivolumab in 582 patients with advanced lung cancer. While the extension of survival was modest in most patients, it is to be remembered that these were patients with advanced lung … Continue reading Lung cancer immunotherapy, from PD-1 knockout mice to clinical trials

Pioneering non-beating heart transplant success – thanks to animal research!

Yesterday a team led by Consultant Surgeon Stephen Large at Papworth Hospital near Cambridge in the UK announced the successful transplant of a non-beating donor heart to heart failure patient Huseyin Ulucan, the first time such an operation has been performed in Europe. Current practice is for donor hearts are obtained when the donor has … Continue reading Pioneering non-beating heart transplant success – thanks to animal research!

Paralyzed man walks again after olfactory cell transplant, thanks to animal research

Today, almost 30 years after Prof. Geoffrey Raisman first identified their potential to repair nerve damage in mice, the BBC reports that olfactory ensheathing cell transplantation has been successfully used to enable Darek Fidyka, who was paralyzed from the chest down in a knife attack in 2010, to walk again. The paper reporting the transplant, … Continue reading Paralyzed man walks again after olfactory cell transplant, thanks to animal research