This morning the Cystic Fibrosis Gene Therapy Consortium (GTC) announced the results of clinical trial in 140 patients with cystic fibrosis, which demonstrate the potential for gene therapy to slow – and potentially halt - the decline of lung function in people with the disorder. It is a success that is built on 25 years … Continue reading Clinical trial success for Cystic Fibrosis gene therapy: built on animal research
Earlier today the BBC reported that European Stroke Research Network for Hypothermia (EuroHYP) has announced the launch of a major clinical trial – involving 1,500 patients in 15 centers across Europe – to evaluate whether cooling the body by 2 degrees can reduce the risk of death and disability in ischaemic stroke. The trial, known … Continue reading Hypothermia in stroke: EuroHYP moves from rats to man
Yesterday I learned some sad news via the Understanding Animal Research blog, that a young woman named Laura Cowell had died, succumbing to cystic fibrosis at the age of just 25. To see a life so full of promise end so prematurely is always sad, but what makes this death so gutting is that Laura … Continue reading Honoring a fallen hero in the struggle against Cystic Fibrosis and AR extremism
To mark the 10th anniversary of the sequencing of the human genome the BBC aired a documentary yesterday evening entitled “Miracle cure: a decade of the human genome” that can be viewed on the BBC iPlayer. It was an enjoyable look at what has been accomplished since the famous announcement at the White House in … Continue reading The First Decade of the Human Genome: What’s on the Horizon?
One of the things that often strikes me when reading about medical advances or clinical trials is how variable the reporting of basic and applied research, including animal research, that underpins the clinical research is. In some cases it is discussed in some depth, but far too often it is either skimmed over or not … Continue reading Finding animal research in medical news
Cystic fibrosis is one of the most commonly inherited diseases, affecting about one in every four thousand children born in the USA, and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene produces a channel that allows the transport of chloride ions across membranes in the body, and … Continue reading A pig model of cystic fibrosis