On Monday Dr Malcolm Macleod, head of experimental neuroscience at the Centre for Clinical Brain Sciences at the University of Edinburgh, joined scientists from the European Stroke Research Network for Hypothermia (EuroHYP) in urging European governments to fund a trial of moderate hypothermia for the treatment of ischemic stroke victims. In ischemic stroke the blood … Continue reading Animal studies point to clinical trial of hypothermia for stroke victims
Multiple sclerosis (MS) is one of the most common diseases of the central nervous system – the brain and spinal cord - affecting about one person in every thousand in the USA. It is an inflammatory condition, where the immune system attacks the myelin sheath that surrounds the axons of nerve cells. Myelin is a … Continue reading From the bench and the bedside; how animal research is taming Multiple Sclerosis
Back in March I discussed a new therapy that combines nanotechnology and RNA interference (RNAi) to treat metastatic melanoma, and how basic and applied animal research has contributed to its’ development. Now researchers at the Georgia Institute of Technology and Emory University have reported the development of another nanotechnology and RNAi approach to treating inflammatory … Continue reading Mice, Nanotechnology, and Inflammatory Bowel Disease
It’s just over a decade since the completion of the first working draft of the human genome was announced, and seven years since the publication of the complete sequence, but in that short time the impact of this new knowledge on all areas medical research has been immense. Sequencing the human genome was a huge … Continue reading Mice, rats, and the secrets of the genome.
When we think of the immune system we usually think of the adaptive immune system - the B-cells and T-cells that recognize and destroy specific pathogens – which isn’t surprising since this is the arm of the immune system that vaccines are designed to stimulate. However working alongside the adaptive immune system is the innate … Continue reading Septic shock: Mice show way to a new treatment
The publication of the preliminary results of a small clinical trial of a new therapy called RNA interference (RNAi) online in the scientific journal Nature is causing quite a stir in the scientific community this week. A team led by Professor Mark E. Davis at Caltech targeted the delivery of a nanoparticle only 70 nanometers … Continue reading RNAi: Send in the Nanobots!