Of Mice and Mammaries, Part 2: Breast cancer in a dish?

In light of Breast Cancer Awareness Month, Justin Varholick traces how mice have helped breast cancer research over the past century. In the second post of this 4-part series, we look at advances made from 1960 to 1975 when scientists were studying a virus in the milk. Last week, in Part 1 of this series, … Continue reading Of Mice and Mammaries, Part 2: Breast cancer in a dish?

En Passage, an Approach to the Use and Provenance of Immortalized Cell Lines

This guest post is by Lisa Krugner-Higby, DVM, PhD.  Dr. Krugner-Higby is a scientist and also a research veterinarian within the Research Animal Resource Center at the University of Wisconsin-Madison. Dr. Krugner-Higby’s research is in development of extended-release formulations of analgesic and antimicrobial drugs. She previously worked in anti-HIV drug development. I am always fascinated … Continue reading En Passage, an Approach to the Use and Provenance of Immortalized Cell Lines

Mice Help Develop Molecular Imaging of Tumors

Can you follow the structural growth and metabolic activity of a developing tumor?   Such an advance would allow one to track how patients are responding to their therapies right away instead of having to wait weeks.  The video shows new research in the field of molecular imaging and yet another example of how the … Continue reading Mice Help Develop Molecular Imaging of Tumors

RNAi: Send in the Nanobots!

The publication of the preliminary results of a small clinical trial of a new therapy called RNA interference (RNAi) online in the scientific journal Nature is causing quite a stir in the scientific community this week.  A team led by Professor Mark E. Davis at Caltech targeted the delivery of a nanoparticle only 70 nanometers … Continue reading RNAi: Send in the Nanobots!

From Mouse to Monkey to Humans: The Story of Rituximab

Modern advances in science have meant that our models of diseases have vastly improved. Be that in a dish in the laboratory, a computer simulation or through using a transgenic mouse, there have been developments across the biomedical field that have given us a greater understanding of diseases and how our bodies work. This increase … Continue reading From Mouse to Monkey to Humans: The Story of Rituximab

Can we protect the brain against tumor metastasis?

Brain metastasis that affect at least 20% of cancer patients are a serious problem for doctors seeking to treat cancer and kill thousands of patients every year, being particularly difficult to treat because many anti-cancer drugs cannot cross the blood-brain barrier and because surgery to remove the tumor can often be difficult and risky.  Patients … Continue reading Can we protect the brain against tumor metastasis?

Taking a BiTE out of non-Hodgkin’s lymphoma

Non-Hodgkin's lymphoma (NHL) is a diverse family of cancers that affect a part of the body's immune system known as the lymphatic system.  In NHL white blood cells become cancerous and develop into tumors at key points in the lymphatic system known as the lymph nodes, before spreading to other tissues.  About 50,000 Americans develop … Continue reading Taking a BiTE out of non-Hodgkin’s lymphoma