Tag Archives: Statistics

USDA publishes 2016 animal research statistics – 7% rise in animal use

The USDA/APHIS has published the 2016 animal research statistics. Overall, the number of animals (covered by the Animal Welfare Act) used in research in the US rose 6.9% from 767,622 (2015) to 820,812 (2016). This includes both public and private institutions.

These statistics do not include all animals as most mice, rats, and fish are not covered by the Animal Welfare Act – though they are still covered by other regulations that protect animal welfare. We also have not included the 137,444 animals which were kept in research facilities in 2016 but were not involved in any research studies.

CC-BY: speakingofresearch.com

Click to Enlarge

The statistics show that 52% of research is on guinea pigs, hamsters and rabbits, 10% is on farm animal species, while 11% is on dogs or cats and 9% on non-human primates. In the UK, where mice, rats, fish and birds are counted in the annual statistics, over 97% of research is on rodents, birds and fish. Across the EU, which measures animal use slightly differently, 93% of research is on species not counted under the Animal Welfare Act (AWA). If similar proportions were applied the US, the total number of vertebrates used in research in the US would be between 12 and 27 million, however, there are no published statistics to confirm this.

CC-BY: speakingofresearch.com

Comparing the 2015 and 2016 statistics there has been a small rise in the use of most species, apart from dogs (down 0.2%) and cats (down 5.2%). The largest rises were found in non-human primates (up 15%) and sheep (up 14%). Furthermore, it should be noted that this 6.9% rise comes a year after an 8% fall, putting the total number of animals used in 2016 slightly below the levels in 2014.

Animals used in researchand testing in the US 1973 - 2016

Trend in number of animals used in research in the US, 1973 – 2016 – Click to Enlarge

There has been a general downward trend in the number of animals used in the US over the past three decades; the number of animals used has more than halved (from 1.8million in 1986), with the use of dogs and cats down by over 65%. It is likely that a move towards using more genetically altered mice and fish has reduced the numbers of many other AWA-covered animals used. That said, non-human primates are one of the few species to have risen in use, from an average of 54,000 animals per year from 1977-2006, to 67,000 in 2007-2016.

In the UK, where mice, rats, fish and birds are counted in the annual statistics, over 97% of research is on rodents, birds and fish. Across the EU, which measures animal use slightly differently, 93% of research is on species not counted under the Animal Welfare Act. If similar proportions were applied the US, the total number of vertebrates used in research in the US would be between 12 and 27 million.

Rises and falls in the number of animals used reflects many factors including the level of biomedical activity in a country, trending areas of research, changes to legislations at home and abroad, outsourcing research to and from other countries, and new technologies (which may either replace animal studies or create reasons for new animal experiments).

The annual statistics are one example of openness and transparency in animal research, but the last few years have seen a greater number of institutions from all over the world publically acknowledging their animal research in statements on their website. This week, two separate openness initiatives were announced, with Americans for Medical Progress launching their “Come See Our World” website of free-to-use animal research images, and Understanding Animal Research promoting a 3D tour of four animal facilities in the UK.

Using the virtual tour you walk around real research facilities like this one at the University of Oxford.

On the subject of openness, it was disappointing that neither the USDA, nor APHIS decided to press release the figures when they were released on June 7th 2017, or even mention them in the website’s News and Announcements. The US could follow the past example of the UK, where the Home Office, in conjunction with the Science Media Centre, held a press conference each year to announce the annual statistics and to offer experts to explain and discuss the numbers.

Source of US Statistics:

Speaking of Research Coverage:

We will continue to bring you the latest national statistics as and when they are released.

Speaking of Research

Animal experiments in Israel rise by 51% in 2016

Israel used 507,018 animals for research and testing on animals in 2016 according to statistics released by The Ministry of Health’s Council for Animal Experimentation. This represents a 51% rise on 2015 – with the increase mainly due to a fourteen-fold increase in the number of cold-blooded mammals used (99% fish).

Testing on Animals in Israel for research in 2016. Click to Enlarge

There were moderate decreases in the number of rabbits, but the huge increase came from cold-blood animals, up from 12,784 in 2015 to 180,253 in 2016. According to the chairman of the National Council for Animal Experimentation, Prof Jacob Gopas, who spoke to Haaretz:

“If it’s possible to use fish, you don’t use mice, for example, and if it’s possible to use mice then you don’t use pigs,” Gopas says. Both the move toward using fish rather than mice in experiments and the efforts being made to raise fish with as few diseases as possible have contributed to the spike in the number of fish being used. Gopas notes that the vast majority of the fish used in research, 154,000 of the 178,000 that were used last year, were returned to their previous habitats.

No cats or dogs have been used in experiments in Israel since 2012. Primate numbers have edged up, increasing from 42 to 46 in 2016, though this is still less than 0.01% of total animal numbers. Primate experiments were under threat in 2014, resulting in seven Nobel Laureates, and seven major universities writing to President Netanyahu urging him not to further restrict animal studies.

Animals used in research in Israel in 2016. Click to Enlarge

Mice are still the most commonly used species in Israel, accounting for 51% of total animal numbers. Fish are the next most common at 35% (36% when other cold-blooded mammals are included). Rats and birds take the next two slots, with 8% and 4% respectively.

Trends in Israeli animal experiments 2004-16. Click to Enlarge.

Historical statistics show that until the spike in 2016, the number of animals has been fairly constant, fluctuating between around 275,000 and 340,000. The slight variations may account for individual projects which used a lot of animals, or from slight changes in science funding over the years. It appears that the sharp rise in 2016 is due to one or more research projects specifically working with fish – that account for most of the 170 thousand rise in animal numbers.

It should also be noted that Israel works hard to rehabilitate animals used in research. According to Israel Hayom,

The council noted that in 2016, its post-testing animal rehabilitation rate for monkeys, carnivores, farm animals and wildlife, excluding rodents and poultry, stood at 88%.

“The rates of animal rehabilitation in Israel are outstanding by any standard. Israel has been a leader in this field for years compared with the data published worldwide,” the council said, adding that it has so far funded nine projects aimed at developing methods that would minimize animal testing by finding alternatives that would not compromise research studies.

More information (in Hewbrew) can be found about the severity of animal experiments in Israel in 2016. The statistics show that 14% of projects were categorised as severe, 31% as moderate, 28% as mild, 18% as below mild, and 9% killed humanely for the purpose of collecting organs (not all countries collect this data). It is likely that projects are estimated at or above the actual severity level, and researchers would be in breach of protocol if they exceed their estimated severity.

Check out all the latest international statistics on our Animal Research Statistics page.

Speaking of Research

monkey animal experiment playing

Monkey on an Israeli primate breeding facility

Sources:

Czech Republic sees 2% fall in animal research numbers for 2016

The Czech Republic has reported a 2.1% fall in the number of animal research procedures in 2016, with 229,465 procedures on animals. This is down from 234,366 procedures in 2015. The falls were mainly in fish (down 11%) and rats (down 17%), while the biggest rise was in birds (up 17%).

Procedures on animals in the Czech Republic for research and testing in 2016. Click to Enlarge

Fish were the most common animal used (35%), followed by mice (33%), birds (13%) and rats (11%). Collectively these four species accounted for over 92% of animal research in the Czech Republic (in line with other European countries). Dogs, cats and primates together continued to account for less than 0.5% of research procedures (919)

The most common areas of research were “basic research” (35.4%),  “Conservation of the natural environment in the interests of the health or welfare of people or animals” (21.0%) and “Translational and applied research” (11.4%).

The trend in animal experiments in the Czech Republic. Click to Enlarge.

The number of animals used since 2013 has remained quite flat, at around 230,000 procedures, though it is not immediately clear why. The drop since 2012 may be a result of the new reporting criteria brought about by EU Directive 2010/63, which came into force in 2014 (though some countries implemented new counting procedures before then).

Source of Czech Statistics: http://eagri.cz/public/web/file/1497/EPZ16t_resorty.pdf

We will continue to bring you the latest national statistics as and when they are released.

Speaking of Research

Slovakia releases 2016 animal research data

Slovakia has become the first EU country to report back on the number of animal procedures it conducted in 2016.

There were 12,855 procedures on animals in Slovakia in 2016, a 5% decline from 2015.

Animal research in Slovakia for 2016 by species [Click to Enlarge]

Rodents accounted for over 95% of research procedures in Slovakia. Less usual, was that there were more rats used than mice – though this was not true in 2015. No dogs were used in 2016 (34 procedures in 2015), and the number of procedures on cats fell from 29 to 11. The main changes were a 13% fall in procedures on mice, and a 59% rise in the use of rabbits.

Looking at the severity statistics, we can see 52% were mild or non-recovery, with 46% moderate (up from 27% in 2015) and 1.2% were severe (down from 2.0% in 2015).

Severity of animal experiments in Slovakia

Other facts found in the 2016 statistics:

  • The most common use of research animals was Basic Research (71.3%), followed by Regulatory use and Routine Production (23.4%), Maintenance of breeding colonies (3.1%) and Translational/Applied research (2.2%).
  • Within the basic research, common areas of study were the Nervous system (30%), Reproductive system (16%) and Immune system (14%).
  • 99.67% of the animals used were bred within the EU
  • No animals were re-used.
  • 7% were genetically modified and 93% were not

Source:
Slovakia: EU Statistical Data of all uses of animals, 2015
Slovakia: EU Statistical Data of all uses of animals, 2016

Speaking of Research

Latest animal research statistics from Belgium, Greece and Poland

Speaking of Research try to keep on top of the latest statistics coming from governments around the world. This post will look at three countries which have recently published their 2015 statistics.

Belgium

Belgium’s three regions (Brussels, Flanders, and Wallonia) independently publish the statistics for their region. We have collated the results (1-3) into a single table covering all of Belgium.

Animal research in Belgium for 2015 by species [Click to Enlarge]

Animal research in Belgium for 2015 by species [Click to Enlarge]

There were 566,603 procedures in Belgium in 2015, down almost 15% from the previous year. The numbers fell in all three regions of Belgium, with the number of procedures in Flanders falling 14%, Brussels falling 7% and Wallonia falling 18%. By species, the biggest falls were in fish (down 24%), rats (down 46%) and guinea pigs (down 19%). This all follows a general downward trend in numbers over the past two decades.

Trends in Belgian animal experiments 1997-2015.

Trends in Belgian animal experiments 1997-2015.

Unusually for a European country, rabbits were used more than rats in 2015 (not true in 2014). Mice, rats, fish and birds still accounted for 87% of research, rising to 85% when rabbits were included.

animal-research-by-species-in-belgium-pie-chart-2015

Links:

(1) Brussels – Statistieken in verband met het gebruik van proefdieren in het brussels hoofdstedelijk gewest in 2015
(2) Flanders – Proefdieren in Vlaanderen in 2015 uitgedrukt in cijfers
(3) Wallonia – Statistiques d’utilisation des animaux dans les experiences en wallonie en 2015
(4) Belgium 2014 Statistics

Greece

Greece published its 2015 statistics recently (5).

Animal research in Greece for 2015 by species [Click to Enlarge]

Animal research in Greece for 2015 by species [Click to Enlarge]

There were 47,784 procedures on animals in Greece in 2015, a rise of 13% (5,541 procedures) from the previous year. Over 97%  were mice, fish, rats and birds (mainly mice and fish). The number of fish more than tripled to 13,817 procedures. Unlike the previous year, there were procedures on cats (47), dogs (4) and primates (3). These species account for less than 0.15% of animals used.

animal-research-by-species-in-greece-pie-chart-2015

The severity statistics show that 70% were classed as non-recovery or mild. 6.5% were classified as severe.

Severity of animal experiments in Greece

Links:

(5) Greece 2015 – Πληροφορίες σχετικά µε τη χρήση ζώων για επιστηµονικούς σκοπούς στην Ελλάδα για το έτος 2015

Poland

After the publication of the 2014 statistics we had to make an editor’s note because we spotted some unusual trends. It turned out that Poland had erroneously added over 400,000 fish to their statistics. We have concerns about the 2015 data which is why we have not written it up in full.

The 2015 statistics show that there were 174,456 procedures on animals in 2015. This is a 25% fall compared with the previous year (6).

This data may be incorrect

This data may be incorrect. See text below.

Our concerns are twofold. Firstly, the number of procedures on fish – 11,561 – is exactly the same as the data for 2014. This seems exceptionally unlikely. Secondly, there appears to be a discrepancy between numbers of animal procedures in the severity tables for 2015, and the numbers in the basic data. For example, the severity tables show 88,776 procedures on mice. The general data for 2015 shows 88,601 procedures.

For these reasons, we recommend caution when using this data. Speaking of Research will continue to try and get to the bottom of this data (as we did for the 2014 statistics).

Links

(6) Poland 2015 – Zwierzęta wykorzystane w procedurach w 2015
(7) Poland 2014 Statistics

Speaking of Research

Canada’s animal research in numbers for 2015

The statistics for animal research conducted in Canada in 2015 have been released by the Canadian Council on Animal Care (CCAC). These numbers reflect research conducted by CCAC-certified institutions and by people working at CCAC-certified institutions, even if the research involves animals located outside of Canada. The criteria for CCAC certification can be found here. This also means that not all animals used for research in Canada are included in these reports. The CCAC reports that in 2015, 3,570,352 animals were used for research, teaching, and testing in Canada. This is a decrease of 4.8% from the 3,750,125 animals that were used in 2014.

Animal research in Canada for 2015 by species [Click to Enlarge]

Animal research in Canada for 2015 by species [Click to Enlarge]

Similar to other countries, mice remain the most popular species used for animal research, with an overall increase of 12%. Fish are a close second in terms of use in 2015, though there was a decrease of 26% in their use compared to 2014. The number of cattle used in research approximately doubled compared to 2014. All other reported species saw decreases in reported use.

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Click to Enlarge

84.2% of the animals used in research and testing were conducted on mice, rats, fish, and birds, which was slightly lower than in other countries. However, with the inclusion of cattle, this percentage rises to 93.9%.  Similarly to other countries, monkeys (4,942), cats (5,035), and dogs (9,573) comprised a small proportion of animals used for research, together accounting for 0.5% of all research animals, with an overall decrease of 5,592 animals from 2014 for these species.

CCAC

Pain, suffering, and harm were also measured and classified under four categories of invasiveness:

  • None: Experiments which cause little of no discomfort or stress
  • Mild: Experiments which cause minor stress or pain of short duration
  • Moderate: Expierments which cause moderate to severe distress or discomfort
  • Severe: Procedures which cause severe pain near, at, or above the pain tolerance threshold of unanesthetized conscious animals.

It is important to understand that every animal in a group will receive the highest category of any single animal in that group, so if a study involved giving different animals different doses of a compound (in a single study), then all animals would receive a category of invasiveness equal to that received by the highest dose group. For further details on what these categories mean, please see here. In 2015, 31.1% of experiments were classified as “none” (this includes studies where the animal are anaesthetised and never woken up), 37.4% were considered “mild”, 29.5% were “moderate”, and 2% were “severe”.

Animals can be used in more than one protocol, provided these additional protocols do not result in pain. Some animals have been counted more than once in this dataset, which is why the total is higher than the total number of animals used in 2015. These data cannot be compared accurately to animal data reports prior to 2012.

Animals can be used in more than one protocol, provided these additional protocols do not result in pain. Some animals have been counted more than once in this dataset, which is why the total is higher than the total number of animals used in 2015. These data cannot be compared accurately to animal data reports prior to 2012.

Overall, there seems to be an upward trend in the number of animals used in research in Canada over the last 20 years, although this pattern is not particularly clear due to annual fluctuations. These fluctuations may be a consequence of the accounting procedures used (which changed in 2012), and may only reflect animals used in CCAC-certified institutions.

Trends in Canadian animal experiments 1996-2015. 2010 data temporarily unavailable due to an accounting error being fixed.

Trends in Canadian animal experiments 1996-2015. 2010 data temporarily unavailable due to an accounting error being fixed.

Finally, the CCAC Animal Data Report 2015 provides some information on animal use. The most common purpose of animal experiments was for basic research (61.2%), followed by “development of products or appliances for human or veterinary medicine” (16.0%); studies into human and animal diseases or disorders (12.9%); Regulatory tests (“animal testing”) (5.5%); and finally education and training (4.4%).

For more information see our Briefing on Animal Research in Canada.

Jeremy Bailoo

Germany’s animal research in numbers for 2015

The statistics for animal research conducted in Germany in 2015 were submitted to the European Commission last week. We have summarised the data below. We compare that to the 2014 statistics also available on their website.

Tierversuche

Animal research in Germany for 2015 by species [Click to Enlarge]

Germany used 2,799,961 animals in 2015, with an overall decrease (15.5%) in animal use when compared to 2014. Similar to other countries, mice remain the most popular species used in animal research, with an increase in use of 5% compared to 2014. Fish, birds, other rodents and other non-mammals saw sizable percentage decreases in their overall use compared to 2014, albeit compared to the total number of animals used, these relative differences are still small. Fish in particular saw a decrease because of differences in reporting between 2014 and 2015. According to the Bundesministerium für Ernährung und Landwirtschaf (BMEL), in 2014, “708,462 “other fish” (including about 563,600 fish larvae) were reported (21.38 percent). By 2015, however, the share of animals in the “other fish” category was only 2.88% (80,777 animals).”

Tierversuche

Mice, rats and fish account for 91% of all animal procedures, rising to 95% if you include rabbits. Similarly to 2014, Germany remains one of the few European countries where rabbits are the fourth most commonly used species in 2015. Dogs, cats and primates accounted for 0.31% of all animals, despite a doubling in the number of animals used for these species.

Tierversuche

Click to Enlarge

This year was the second year where there was retrospective assessment and reporting of severity (i.e. reporting how much an animal actually suffered rather than how much it was predicted to suffer prior to the study). The report showed that 43% of procedures were classed as mild, 17% as moderate, 4% as severe, and 36% as non-recovery, where an animal is anaesthetised for surgery, and then not woken up afterwards. Compared to 2014, there were some noticeable shifts in relation to severity. While the number of procedures which caused animals moderate and severe levels of stress and distress decreased, the numbers of procedures that were terminal increased.

Severity of animal experiments in Germany

Click to Enlarge

Looking at the historical data, we see that like several other countries, the number of animal experiments increased steadily between 2000-2012. The sharp increase in 2014 followed by a decrease in 2015, reflect in part differences in the accounting procedures used between 2014 and 2015. Thus, it is too early to say whether the fall in 2015 is a one-off or a sign of a future drop-off in animal experiments. It is likely that this drop also partly reflects a decrease in funding to science during the recession and economic turmoil of the past few years. Next year’s data may provide some insight into whether and how this trend will continue.

Trends in German animal experiments 2000-15. Click to Enlarge.

Trends in German animal experiments 2000-15. Click to Enlarge.

Other interesting information provided by the annual statistical release includes:

  • 8% of animals used were bred within the EU [Table 3]
  • The main purpose of research was “Basic Research” (58.7%), followed by “Regulatory use and Routine production” (22.5%), “Maintenance of colonies of established genetically altered animals, not used in other procedures”, “Translational and applied Research” (13.6%), and all other uses (5.2 %) [Table 9]
  • Two-thirds of the total dogs, cats and primates were used for Regulatory testing [Table 9]
  • 40% of animals were genetically altered, compared with 60% which were not. Over 98% of the genetically altered animals were mice or zebrafish [Table 20]

For further information about animal research (Tierversuche) in Germany see our background briefing, available in English and German.

Speaking of Research

2015 Statistics: http://www.bmel.de/SharedDocs/Downloads/Tier/Tierschutz/Versuchstierdaten2015.pdf?__blob=publicationFile

2014 Statistics: http://www.bmel.de/SharedDocs/Downloads/Tier/Tierschutz/Versuchstierdaten2014.pdf?__blob=publicationFile

N.B. Some our more eagle-eyed readers may have noted the 2014 statistics referenced in this article do not correspond to those we published a year ago. This is because the German authorities changed the counting methodologies for 2015 and re-released an altered 2014 statistics so that they could be fairly compared to the 2015 data.