Human mRNA vaccine trials in the 2010s? A history lesson in animal research

The recent mRNA vaccines for COVID-19 are the first of their kind, but they weren’t created overnight. RNA itself was discovered in the 1960s. Then, basic research in the 1970s paved the way for vaccine development in the 90s, optimization in the 2000s, clinical trials for influenza and rabies in the late 2010s

Advances from Animal Research: AIDS and Zika Vaccines Update

April 19th, 2021Professor Christopher Petkov Although we have been focusing on updates on Covid-19 vaccines and their reliance on research with nonhuman animals including primates (as an example post see here), two other developments focusing on treatments for AIDS and Zika fever have caught our eye. These fall under the topic #MPAR, Made Possible by … Continue reading Advances from Animal Research: AIDS and Zika Vaccines Update

Animal models paved the way for Phase III testing of the COVID-19 vaccine

Yesterday, NIH and Moderna announced the start of a multi-site, Phase 3 clinical trial of a candidate vaccine for COVID-19. This candidate vaccine uses messenger RNA, or mRNA, a “codebook” that cellular machinery “reads” in order to build proteins. For this candidate vaccine, the mRNA contains instructions for building spike proteins found on the coronavirus, … Continue reading Animal models paved the way for Phase III testing of the COVID-19 vaccine

Ebola Vaccine, four decades in the making

Recent news indicates that the Ebola virus is spreading throughout the northern region of the Democratic Republic of Congo, including one case in Mbandaka, a city with a population of 1 million. Many people will remember the outbreak in 2014 that led to more than 10,000 deaths in West Africa. In efforts to curb a new outbreak, the … Continue reading Ebola Vaccine, four decades in the making

Research Roundup: Malaria vaccine, mouse sperm in space, animal welfare prizes, and more!

Welcome to this week’s Research Roundup. These Friday posts aim to inform our readers about the many stories that relate to animal research each week. Do you have an animal research story we should include in next week’s Research Roundup? You can send it to us via our Facebook page or through the contact form … Continue reading Research Roundup: Malaria vaccine, mouse sperm in space, animal welfare prizes, and more!

HPV vaccines and cervical cancer – a success in animals is a success for humans

A recent article in the journal Pediatrics reported that vaccination against human papilloma virus (HPV) resulted in a 64% reduction in infections in girls aged 14-19 (1). The vaccine, Gardasil, came onto market in June of 2006 and protects again four different HPV types: the two most prevalent high-risk viruses, HPV16 and HPV18, and the … Continue reading HPV vaccines and cervical cancer – a success in animals is a success for humans

One step closer to a vaccine for cytomegalovirus: Monkeys transmit CMV the same way as humans

Today's guest post is by Jordana Lenon, Wisconsin National Primate Research Center and Kathy West, California National Primate Research Center. Researchers at Duke and Tulane take the lead, the National Primate Research Centers provide critical resources and expertise in this first-ever proof of CMV placental transmission in nonhuman primates. Researchers now have a powerful new … Continue reading One step closer to a vaccine for cytomegalovirus: Monkeys transmit CMV the same way as humans